Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring

Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with a multifactorial, multistep, complex process and poor prognosis. Its early diagnosis and metastasis monitoring are of the utmost importance. Hepatoma tissues synthesize various tumor-related protei...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Li, Yao, Min, Dong, Zhizhen, Zhang, Yun, Yao, Dengfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907675/
https://www.ncbi.nlm.nih.gov/pubmed/24006223
http://dx.doi.org/10.1007/s13277-013-1141-0
_version_ 1782301633207599104
author Wang, Li
Yao, Min
Dong, Zhizhen
Zhang, Yun
Yao, Dengfu
author_facet Wang, Li
Yao, Min
Dong, Zhizhen
Zhang, Yun
Yao, Dengfu
author_sort Wang, Li
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with a multifactorial, multistep, complex process and poor prognosis. Its early diagnosis and metastasis monitoring are of the utmost importance. Hepatoma tissues synthesize various tumor-related proteins, genes, enzymes, microRNA, etc. and then secrete into the blood. Detections of circulating biomarkers are useful to find tumor at an early stage or monitor metastasis after postoperative treatment. This paper summarizes recent studies of specific biomarkers at early diagnosis or in monitoring metastasis or postoperative recurrence of HCC.
format Online
Article
Text
id pubmed-3907675
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-39076752014-02-04 Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring Wang, Li Yao, Min Dong, Zhizhen Zhang, Yun Yao, Dengfu Tumour Biol Review Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with a multifactorial, multistep, complex process and poor prognosis. Its early diagnosis and metastasis monitoring are of the utmost importance. Hepatoma tissues synthesize various tumor-related proteins, genes, enzymes, microRNA, etc. and then secrete into the blood. Detections of circulating biomarkers are useful to find tumor at an early stage or monitor metastasis after postoperative treatment. This paper summarizes recent studies of specific biomarkers at early diagnosis or in monitoring metastasis or postoperative recurrence of HCC. Springer Netherlands 2013-09-05 /pmc/articles/PMC3907675/ /pubmed/24006223 http://dx.doi.org/10.1007/s13277-013-1141-0 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Wang, Li
Yao, Min
Dong, Zhizhen
Zhang, Yun
Yao, Dengfu
Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring
title Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring
title_full Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring
title_fullStr Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring
title_full_unstemmed Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring
title_short Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring
title_sort circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907675/
https://www.ncbi.nlm.nih.gov/pubmed/24006223
http://dx.doi.org/10.1007/s13277-013-1141-0
work_keys_str_mv AT wangli circulatingspecificbiomarkersindiagnosisofhepatocellularcarcinomaanditsmetastasismonitoring
AT yaomin circulatingspecificbiomarkersindiagnosisofhepatocellularcarcinomaanditsmetastasismonitoring
AT dongzhizhen circulatingspecificbiomarkersindiagnosisofhepatocellularcarcinomaanditsmetastasismonitoring
AT zhangyun circulatingspecificbiomarkersindiagnosisofhepatocellularcarcinomaanditsmetastasismonitoring
AT yaodengfu circulatingspecificbiomarkersindiagnosisofhepatocellularcarcinomaanditsmetastasismonitoring

Ejemplares similares