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Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development
We show that neural crest stem cells affect mouse hair follicle development. During embryogenesis hair follicle induction is regulated by complex reciprocal and functionally redundant signals between epidermis and dermis, which remain to be fully understood. Canonical Wnt signalling is a hallmark of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907677/ https://www.ncbi.nlm.nih.gov/pubmed/23955574 http://dx.doi.org/10.1007/s12015-013-9466-z |
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author | Narytnyk, Alla Gillinder, Kevin Verdon, Bernard Clewes, Oliver Sieber-Blum, Maya |
author_facet | Narytnyk, Alla Gillinder, Kevin Verdon, Bernard Clewes, Oliver Sieber-Blum, Maya |
author_sort | Narytnyk, Alla |
collection | PubMed |
description | We show that neural crest stem cells affect mouse hair follicle development. During embryogenesis hair follicle induction is regulated by complex reciprocal and functionally redundant signals between epidermis and dermis, which remain to be fully understood. Canonical Wnt signalling is a hallmark of neural crest cells and also a prerequisite for hair follicle induction prior to hair placode formation in the epidermis. As neural crest stem cells invade the epidermis during early embryonic development we aimed at determining whether neural crest cells affect hair follicle development. To attenuate, but not silence, canonical Wnt signalling specifically in neural crest cells, we analyzed Wnt1-cre(+/−)::Pygo2(−/−) mice in which the β-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells. Both, hair density and hair thickness were reduced in mutant mice. Furthermore, hair development was delayed and the relative ratio of hair types was affected. There was a decrease in zig-zag hairs and an increase in awl hairs. Mouse neural crest stem cells expressed ectodysplasin, an essential effector in the formation of zig-zag hair. Taken together, our data support the novel notion that neural crest cells are involved in the earliest stages of hair follicle development. |
format | Online Article Text |
id | pubmed-3907677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-39076772014-02-04 Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development Narytnyk, Alla Gillinder, Kevin Verdon, Bernard Clewes, Oliver Sieber-Blum, Maya Stem Cell Rev Article We show that neural crest stem cells affect mouse hair follicle development. During embryogenesis hair follicle induction is regulated by complex reciprocal and functionally redundant signals between epidermis and dermis, which remain to be fully understood. Canonical Wnt signalling is a hallmark of neural crest cells and also a prerequisite for hair follicle induction prior to hair placode formation in the epidermis. As neural crest stem cells invade the epidermis during early embryonic development we aimed at determining whether neural crest cells affect hair follicle development. To attenuate, but not silence, canonical Wnt signalling specifically in neural crest cells, we analyzed Wnt1-cre(+/−)::Pygo2(−/−) mice in which the β-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells. Both, hair density and hair thickness were reduced in mutant mice. Furthermore, hair development was delayed and the relative ratio of hair types was affected. There was a decrease in zig-zag hairs and an increase in awl hairs. Mouse neural crest stem cells expressed ectodysplasin, an essential effector in the formation of zig-zag hair. Taken together, our data support the novel notion that neural crest cells are involved in the earliest stages of hair follicle development. Springer US 2013-08-18 2014 /pmc/articles/PMC3907677/ /pubmed/23955574 http://dx.doi.org/10.1007/s12015-013-9466-z Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Article Narytnyk, Alla Gillinder, Kevin Verdon, Bernard Clewes, Oliver Sieber-Blum, Maya Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development |
title | Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development |
title_full | Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development |
title_fullStr | Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development |
title_full_unstemmed | Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development |
title_short | Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development |
title_sort | neural crest stem cell-specific deletion of the pygopus2 gene modulates hair follicle development |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907677/ https://www.ncbi.nlm.nih.gov/pubmed/23955574 http://dx.doi.org/10.1007/s12015-013-9466-z |
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