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Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development

We show that neural crest stem cells affect mouse hair follicle development. During embryogenesis hair follicle induction is regulated by complex reciprocal and functionally redundant signals between epidermis and dermis, which remain to be fully understood. Canonical Wnt signalling is a hallmark of...

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Autores principales: Narytnyk, Alla, Gillinder, Kevin, Verdon, Bernard, Clewes, Oliver, Sieber-Blum, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907677/
https://www.ncbi.nlm.nih.gov/pubmed/23955574
http://dx.doi.org/10.1007/s12015-013-9466-z
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author Narytnyk, Alla
Gillinder, Kevin
Verdon, Bernard
Clewes, Oliver
Sieber-Blum, Maya
author_facet Narytnyk, Alla
Gillinder, Kevin
Verdon, Bernard
Clewes, Oliver
Sieber-Blum, Maya
author_sort Narytnyk, Alla
collection PubMed
description We show that neural crest stem cells affect mouse hair follicle development. During embryogenesis hair follicle induction is regulated by complex reciprocal and functionally redundant signals between epidermis and dermis, which remain to be fully understood. Canonical Wnt signalling is a hallmark of neural crest cells and also a prerequisite for hair follicle induction prior to hair placode formation in the epidermis. As neural crest stem cells invade the epidermis during early embryonic development we aimed at determining whether neural crest cells affect hair follicle development. To attenuate, but not silence, canonical Wnt signalling specifically in neural crest cells, we analyzed Wnt1-cre(+/−)::Pygo2(−/−) mice in which the β-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells. Both, hair density and hair thickness were reduced in mutant mice. Furthermore, hair development was delayed and the relative ratio of hair types was affected. There was a decrease in zig-zag hairs and an increase in awl hairs. Mouse neural crest stem cells expressed ectodysplasin, an essential effector in the formation of zig-zag hair. Taken together, our data support the novel notion that neural crest cells are involved in the earliest stages of hair follicle development.
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spelling pubmed-39076772014-02-04 Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development Narytnyk, Alla Gillinder, Kevin Verdon, Bernard Clewes, Oliver Sieber-Blum, Maya Stem Cell Rev Article We show that neural crest stem cells affect mouse hair follicle development. During embryogenesis hair follicle induction is regulated by complex reciprocal and functionally redundant signals between epidermis and dermis, which remain to be fully understood. Canonical Wnt signalling is a hallmark of neural crest cells and also a prerequisite for hair follicle induction prior to hair placode formation in the epidermis. As neural crest stem cells invade the epidermis during early embryonic development we aimed at determining whether neural crest cells affect hair follicle development. To attenuate, but not silence, canonical Wnt signalling specifically in neural crest cells, we analyzed Wnt1-cre(+/−)::Pygo2(−/−) mice in which the β-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells. Both, hair density and hair thickness were reduced in mutant mice. Furthermore, hair development was delayed and the relative ratio of hair types was affected. There was a decrease in zig-zag hairs and an increase in awl hairs. Mouse neural crest stem cells expressed ectodysplasin, an essential effector in the formation of zig-zag hair. Taken together, our data support the novel notion that neural crest cells are involved in the earliest stages of hair follicle development. Springer US 2013-08-18 2014 /pmc/articles/PMC3907677/ /pubmed/23955574 http://dx.doi.org/10.1007/s12015-013-9466-z Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Narytnyk, Alla
Gillinder, Kevin
Verdon, Bernard
Clewes, Oliver
Sieber-Blum, Maya
Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development
title Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development
title_full Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development
title_fullStr Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development
title_full_unstemmed Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development
title_short Neural Crest Stem Cell-specific Deletion of the Pygopus2 Gene Modulates Hair Follicle Development
title_sort neural crest stem cell-specific deletion of the pygopus2 gene modulates hair follicle development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907677/
https://www.ncbi.nlm.nih.gov/pubmed/23955574
http://dx.doi.org/10.1007/s12015-013-9466-z
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