Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target()

Ebselen is a synthetic, lipid-soluble seleno-organic compound. The high electrophilicity of ebselen enables it to react with multiple cysteine residues of various proteins. Despite extensive research on ebselen, its target molecules and mechanism of action remains less understood. We performed bioch...

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Detalles Bibliográficos
Autores principales: Azad, Gajendra Kumar, Singh, Vikash, Mandal, Papita, Singh, Prabhat, Golla, Upendarrao, Baranwal, Shivani, Chauhan, Sakshi, Tomar, Raghuvir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907691/
https://www.ncbi.nlm.nih.gov/pubmed/24490132
http://dx.doi.org/10.1016/j.fob.2014.01.002

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