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The VTLISFG motif in the BH1 domain plays a significant role in regulating the degradation of Mcl-1()
Mcl-1 is a member of the Bcl-2 family protein; its degradation is required for the initiation of apoptosis. The mechanism, however, is not yet clearly known. Previously, it was reported that Mcl-1 is degraded through the ubiquitination-mediated pathway and the PEST domain is the motif responsible fo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907746/ https://www.ncbi.nlm.nih.gov/pubmed/24490139 http://dx.doi.org/10.1016/j.fob.2014.01.006 |