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The VTLISFG motif in the BH1 domain plays a significant role in regulating the degradation of Mcl-1()

Mcl-1 is a member of the Bcl-2 family protein; its degradation is required for the initiation of apoptosis. The mechanism, however, is not yet clearly known. Previously, it was reported that Mcl-1 is degraded through the ubiquitination-mediated pathway and the PEST domain is the motif responsible fo...

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Detalles Bibliográficos
Autores principales:	Xiao, Kang, Chen, Pengxuan, Chang, Donald Choy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907746/ https://www.ncbi.nlm.nih.gov/pubmed/24490139 http://dx.doi.org/10.1016/j.fob.2014.01.006

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