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Effects of age-related hearing loss and background noise on neuromagnetic activity from auditory cortex

Aging is often accompanied by hearing loss, which impacts how sounds are processed and represented along the ascending auditory pathways and within the auditory cortices. Here, we assess the impact of mild binaural hearing loss on the older adults’ ability to both process complex sounds embedded in...

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Autores principales: Alain, Claude, Roye, Anja, Salloum, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907769/
https://www.ncbi.nlm.nih.gov/pubmed/24550790
http://dx.doi.org/10.3389/fnsys.2014.00008
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author Alain, Claude
Roye, Anja
Salloum, Claire
author_facet Alain, Claude
Roye, Anja
Salloum, Claire
author_sort Alain, Claude
collection PubMed
description Aging is often accompanied by hearing loss, which impacts how sounds are processed and represented along the ascending auditory pathways and within the auditory cortices. Here, we assess the impact of mild binaural hearing loss on the older adults’ ability to both process complex sounds embedded in noise and to segregate a mistuned harmonic in an otherwise periodic stimulus. We measured auditory evoked fields (AEFs) using magnetoencephalography while participants were presented with complex tones that had either all harmonics in tune or had the third harmonic mistuned by 4 or 16% of its original value. The tones (75 dB sound pressure level, SPL) were presented without, with low (45 dBA SPL), or with moderate (65 dBA SPL) Gaussian noise. For each participant, we modeled the AEFs with a pair of dipoles in the superior temporal plane. We then examined the effects of hearing loss and noise on the amplitude and latency of the resulting source waveforms. In the present study, results revealed that similar noise-induced increases in N1m were present in older adults with and without hearing loss. Our results also showed that the P1m amplitude was larger in the hearing impaired than in the normal-hearing adults. In addition, the object-related negativity (ORN) elicited by the mistuned harmonic was larger in hearing impaired listeners. The enhanced P1m and ORN amplitude in the hearing impaired older adults suggests that hearing loss increased neural excitability in auditory cortices, which could be related to deficits in inhibitory control.
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spelling pubmed-39077692014-02-18 Effects of age-related hearing loss and background noise on neuromagnetic activity from auditory cortex Alain, Claude Roye, Anja Salloum, Claire Front Syst Neurosci Neuroscience Aging is often accompanied by hearing loss, which impacts how sounds are processed and represented along the ascending auditory pathways and within the auditory cortices. Here, we assess the impact of mild binaural hearing loss on the older adults’ ability to both process complex sounds embedded in noise and to segregate a mistuned harmonic in an otherwise periodic stimulus. We measured auditory evoked fields (AEFs) using magnetoencephalography while participants were presented with complex tones that had either all harmonics in tune or had the third harmonic mistuned by 4 or 16% of its original value. The tones (75 dB sound pressure level, SPL) were presented without, with low (45 dBA SPL), or with moderate (65 dBA SPL) Gaussian noise. For each participant, we modeled the AEFs with a pair of dipoles in the superior temporal plane. We then examined the effects of hearing loss and noise on the amplitude and latency of the resulting source waveforms. In the present study, results revealed that similar noise-induced increases in N1m were present in older adults with and without hearing loss. Our results also showed that the P1m amplitude was larger in the hearing impaired than in the normal-hearing adults. In addition, the object-related negativity (ORN) elicited by the mistuned harmonic was larger in hearing impaired listeners. The enhanced P1m and ORN amplitude in the hearing impaired older adults suggests that hearing loss increased neural excitability in auditory cortices, which could be related to deficits in inhibitory control. Frontiers Media S.A. 2014-01-31 /pmc/articles/PMC3907769/ /pubmed/24550790 http://dx.doi.org/10.3389/fnsys.2014.00008 Text en Copyright © 2014 Alain, Roye and Salloum. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Alain, Claude
Roye, Anja
Salloum, Claire
Effects of age-related hearing loss and background noise on neuromagnetic activity from auditory cortex
title Effects of age-related hearing loss and background noise on neuromagnetic activity from auditory cortex
title_full Effects of age-related hearing loss and background noise on neuromagnetic activity from auditory cortex
title_fullStr Effects of age-related hearing loss and background noise on neuromagnetic activity from auditory cortex
title_full_unstemmed Effects of age-related hearing loss and background noise on neuromagnetic activity from auditory cortex
title_short Effects of age-related hearing loss and background noise on neuromagnetic activity from auditory cortex
title_sort effects of age-related hearing loss and background noise on neuromagnetic activity from auditory cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907769/
https://www.ncbi.nlm.nih.gov/pubmed/24550790
http://dx.doi.org/10.3389/fnsys.2014.00008
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