Advanced Glycation End Product-Induced Astrocytic Differentiation of Cultured Neurospheres through Inhibition of Notch-Hes1 Pathway-Mediated Neurogenesis

This study aims to investigate the roles of the Notch-Hes1 pathway in the advanced glycation end product (AGE)-mediated differentiation of neural stem cells (NSCs). We prepared pLentiLox3.7 lentiviral vectors that express short hairpin RNA (shRNA) against Notch1 and transfected it into NSCs. Cell di...

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Detalles Bibliográficos
Autores principales: Guo, Yijing, Wang, Pin, Sun, Haixia, Cai, Rongrong, Xia, Wenqing, Wang, Shaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907803/
https://www.ncbi.nlm.nih.gov/pubmed/24366068
http://dx.doi.org/10.3390/ijms15010159

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