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Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase

This study reports a new type of drug-loaded core-shell nanofibers capable of providing dual controlled release with tunable dose in the second phase. The core-shell nanofibers were fabricated through a modified coaxial electrospinning using a Teflon-coated concentric spinneret. Poly(vinyl pyrrolido...

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Detalles Bibliográficos
Autores principales: Qian, Wei, Yu, Deng-Guang, Li, Ying, Liao, Yao-Zu, Wang, Xia, Wang, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907837/
https://www.ncbi.nlm.nih.gov/pubmed/24406731
http://dx.doi.org/10.3390/ijms15010774
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author Qian, Wei
Yu, Deng-Guang
Li, Ying
Liao, Yao-Zu
Wang, Xia
Wang, Lu
author_facet Qian, Wei
Yu, Deng-Guang
Li, Ying
Liao, Yao-Zu
Wang, Xia
Wang, Lu
author_sort Qian, Wei
collection PubMed
description This study reports a new type of drug-loaded core-shell nanofibers capable of providing dual controlled release with tunable dose in the second phase. The core-shell nanofibers were fabricated through a modified coaxial electrospinning using a Teflon-coated concentric spinneret. Poly(vinyl pyrrolidone) and ethyl cellulose were used as the shell and core polymer matrices respectively, and the content of active ingredient acetaminophen (APAP) in the core was programmed. The Teflon-coated concentric spinneret may facilitate the efficacious and stable preparation of core-shell nanofibers through the modified coaxial electrospinning, where the core fluids were electrospinnable and the shell fluid had no electrospinnability. The resultant nanofibers had linear morphologies and clear core-shell structures, as observed by the scanning and transmission electron microscopic images. APAP was amorphously distributed in the shell and core polymer matrices due to the favorite second-order interactions, as indicated by the X-ray diffraction and FTIR spectroscopic tests. The results from the in vitro dissolution tests demonstrated that the core-shell nanofibers were able to furnish the desired dual drug controlled-release profiles with a tunable drug release amount in the second phase. The modified coaxial electrospinning is a useful tool to generate nanostructures with a tailored components and compositions in their different parts, and thus to realize the desired functional performances.
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spelling pubmed-39078372014-01-31 Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase Qian, Wei Yu, Deng-Guang Li, Ying Liao, Yao-Zu Wang, Xia Wang, Lu Int J Mol Sci Article This study reports a new type of drug-loaded core-shell nanofibers capable of providing dual controlled release with tunable dose in the second phase. The core-shell nanofibers were fabricated through a modified coaxial electrospinning using a Teflon-coated concentric spinneret. Poly(vinyl pyrrolidone) and ethyl cellulose were used as the shell and core polymer matrices respectively, and the content of active ingredient acetaminophen (APAP) in the core was programmed. The Teflon-coated concentric spinneret may facilitate the efficacious and stable preparation of core-shell nanofibers through the modified coaxial electrospinning, where the core fluids were electrospinnable and the shell fluid had no electrospinnability. The resultant nanofibers had linear morphologies and clear core-shell structures, as observed by the scanning and transmission electron microscopic images. APAP was amorphously distributed in the shell and core polymer matrices due to the favorite second-order interactions, as indicated by the X-ray diffraction and FTIR spectroscopic tests. The results from the in vitro dissolution tests demonstrated that the core-shell nanofibers were able to furnish the desired dual drug controlled-release profiles with a tunable drug release amount in the second phase. The modified coaxial electrospinning is a useful tool to generate nanostructures with a tailored components and compositions in their different parts, and thus to realize the desired functional performances. Molecular Diversity Preservation International (MDPI) 2014-01-08 /pmc/articles/PMC3907837/ /pubmed/24406731 http://dx.doi.org/10.3390/ijms15010774 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Qian, Wei
Yu, Deng-Guang
Li, Ying
Liao, Yao-Zu
Wang, Xia
Wang, Lu
Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase
title Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase
title_full Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase
title_fullStr Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase
title_full_unstemmed Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase
title_short Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase
title_sort dual drug release electrospun core-shell nanofibers with tunable dose in the second phase
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907837/
https://www.ncbi.nlm.nih.gov/pubmed/24406731
http://dx.doi.org/10.3390/ijms15010774
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