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Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials

Fractional exhaled nitric oxide (FENO) measurement is a useful diagnostic test of airway inflammation. However, there have been few studies of FENO in workers exposed to nanomaterials. The purpose of this study was to examine the effect of nanoparticle (NP) exposure on FENO and to assess whether the...

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Autores principales: Wu, Wei-Te, Liao, Hui-Yi, Chung, Yu-Teh, Li, Wan-Fen, Tsou, Tsui-Chun, Li, Lih-Ann, Lin, Ming-Hsiu, Ho, Jiune-Jye, Wu, Trong-Neng, Liou, Saou-Hsing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907844/
https://www.ncbi.nlm.nih.gov/pubmed/24413755
http://dx.doi.org/10.3390/ijms15010878
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author Wu, Wei-Te
Liao, Hui-Yi
Chung, Yu-Teh
Li, Wan-Fen
Tsou, Tsui-Chun
Li, Lih-Ann
Lin, Ming-Hsiu
Ho, Jiune-Jye
Wu, Trong-Neng
Liou, Saou-Hsing
author_facet Wu, Wei-Te
Liao, Hui-Yi
Chung, Yu-Teh
Li, Wan-Fen
Tsou, Tsui-Chun
Li, Lih-Ann
Lin, Ming-Hsiu
Ho, Jiune-Jye
Wu, Trong-Neng
Liou, Saou-Hsing
author_sort Wu, Wei-Te
collection PubMed
description Fractional exhaled nitric oxide (FENO) measurement is a useful diagnostic test of airway inflammation. However, there have been few studies of FENO in workers exposed to nanomaterials. The purpose of this study was to examine the effect of nanoparticle (NP) exposure on FENO and to assess whether the FENO is increased in workers exposed to nanomaterials (NM). In this study, both exposed workers and non-exposed controls were recruited from NM handling plants in Taiwan. A total of 437 subjects (exposed group = 241, non-exposed group = 196) completed the FENO and spirometric measurements from 2009–2011. The authors used a control-banding (CB) matrix to categorize the risk level of each participant. In a multivariate linear regression analysis, this study found a significant association between risk level 2 of NP exposure and FENO. Furthermore, asthma, allergic rhinitis, peak expiratory flow rate (PEFR), and NF-κB were also significantly associated with FENO. When the multivariate logistic regression model was adjusted for confounders, nano-TiO(2) in all of the NM exposed categories had a significantly increased risk in FENO > 35 ppb. This study found associations between the risk level of NP exposure and FENO (particularly noteworthy for Nano-TiO(2)). Monitoring FENO in the lung could open up a window into the role nitric oxide (NO) may play in pathogenesis.
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spelling pubmed-39078442014-01-31 Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials Wu, Wei-Te Liao, Hui-Yi Chung, Yu-Teh Li, Wan-Fen Tsou, Tsui-Chun Li, Lih-Ann Lin, Ming-Hsiu Ho, Jiune-Jye Wu, Trong-Neng Liou, Saou-Hsing Int J Mol Sci Article Fractional exhaled nitric oxide (FENO) measurement is a useful diagnostic test of airway inflammation. However, there have been few studies of FENO in workers exposed to nanomaterials. The purpose of this study was to examine the effect of nanoparticle (NP) exposure on FENO and to assess whether the FENO is increased in workers exposed to nanomaterials (NM). In this study, both exposed workers and non-exposed controls were recruited from NM handling plants in Taiwan. A total of 437 subjects (exposed group = 241, non-exposed group = 196) completed the FENO and spirometric measurements from 2009–2011. The authors used a control-banding (CB) matrix to categorize the risk level of each participant. In a multivariate linear regression analysis, this study found a significant association between risk level 2 of NP exposure and FENO. Furthermore, asthma, allergic rhinitis, peak expiratory flow rate (PEFR), and NF-κB were also significantly associated with FENO. When the multivariate logistic regression model was adjusted for confounders, nano-TiO(2) in all of the NM exposed categories had a significantly increased risk in FENO > 35 ppb. This study found associations between the risk level of NP exposure and FENO (particularly noteworthy for Nano-TiO(2)). Monitoring FENO in the lung could open up a window into the role nitric oxide (NO) may play in pathogenesis. Molecular Diversity Preservation International (MDPI) 2014-01-09 /pmc/articles/PMC3907844/ /pubmed/24413755 http://dx.doi.org/10.3390/ijms15010878 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Wei-Te
Liao, Hui-Yi
Chung, Yu-Teh
Li, Wan-Fen
Tsou, Tsui-Chun
Li, Lih-Ann
Lin, Ming-Hsiu
Ho, Jiune-Jye
Wu, Trong-Neng
Liou, Saou-Hsing
Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials
title Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials
title_full Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials
title_fullStr Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials
title_full_unstemmed Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials
title_short Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials
title_sort effect of nanoparticles exposure on fractional exhaled nitric oxide (feno) in workers exposed to nanomaterials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907844/
https://www.ncbi.nlm.nih.gov/pubmed/24413755
http://dx.doi.org/10.3390/ijms15010878
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