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Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology
Hydrogels and, in particular, supramolecular hydrogels show promising properties for application in regenerative medicine because of their ability to adapt to the natural environment these materials are brought into. However, only few studies focus on the structure-property relationships in supramol...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907858/ https://www.ncbi.nlm.nih.gov/pubmed/24441567 http://dx.doi.org/10.3390/ijms15011096 |
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author | Pape, A. C. H. Bastings, Maartje M. C. Kieltyka, Roxanne E. Wyss, Hans M. Voets, Ilja K. Meijer, E. W. Dankers, Patricia Y. W. |
author_facet | Pape, A. C. H. Bastings, Maartje M. C. Kieltyka, Roxanne E. Wyss, Hans M. Voets, Ilja K. Meijer, E. W. Dankers, Patricia Y. W. |
author_sort | Pape, A. C. H. |
collection | PubMed |
description | Hydrogels and, in particular, supramolecular hydrogels show promising properties for application in regenerative medicine because of their ability to adapt to the natural environment these materials are brought into. However, only few studies focus on the structure-property relationships in supramolecular hydrogels. Here, we study in detail both the structure and the mechanical properties of such a network, composed of poly(ethylene glycol), end-functionalized with ureido-pyrimidinone fourfold hydrogen bonding units. This network is responsive to triggers such as concentration, temperature and pH. To obtain more insight into the sol-gel transition of the system, both rheology and small-angle X-ray scattering (SAXS) are used. We show that the sol-gel transitions based on these three triggers, as measured by rheology, coincide with the appearance of a structural feature in SAXS. We attribute this feature to the presence of hydrophobic domains where cross-links are formed. These results provide more insight into the mechanism of network formation in these materials, which can be exploited for tailoring their behavior for biomedical applications, where one of the triggers discussed might be used. |
format | Online Article Text |
id | pubmed-3907858 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-39078582014-01-31 Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology Pape, A. C. H. Bastings, Maartje M. C. Kieltyka, Roxanne E. Wyss, Hans M. Voets, Ilja K. Meijer, E. W. Dankers, Patricia Y. W. Int J Mol Sci Article Hydrogels and, in particular, supramolecular hydrogels show promising properties for application in regenerative medicine because of their ability to adapt to the natural environment these materials are brought into. However, only few studies focus on the structure-property relationships in supramolecular hydrogels. Here, we study in detail both the structure and the mechanical properties of such a network, composed of poly(ethylene glycol), end-functionalized with ureido-pyrimidinone fourfold hydrogen bonding units. This network is responsive to triggers such as concentration, temperature and pH. To obtain more insight into the sol-gel transition of the system, both rheology and small-angle X-ray scattering (SAXS) are used. We show that the sol-gel transitions based on these three triggers, as measured by rheology, coincide with the appearance of a structural feature in SAXS. We attribute this feature to the presence of hydrophobic domains where cross-links are formed. These results provide more insight into the mechanism of network formation in these materials, which can be exploited for tailoring their behavior for biomedical applications, where one of the triggers discussed might be used. Molecular Diversity Preservation International (MDPI) 2014-01-16 /pmc/articles/PMC3907858/ /pubmed/24441567 http://dx.doi.org/10.3390/ijms15011096 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Pape, A. C. H. Bastings, Maartje M. C. Kieltyka, Roxanne E. Wyss, Hans M. Voets, Ilja K. Meijer, E. W. Dankers, Patricia Y. W. Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology |
title | Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology |
title_full | Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology |
title_fullStr | Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology |
title_full_unstemmed | Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology |
title_short | Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology |
title_sort | mesoscale characterization of supramolecular transient networks using saxs and rheology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907858/ https://www.ncbi.nlm.nih.gov/pubmed/24441567 http://dx.doi.org/10.3390/ijms15011096 |
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