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Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology

Hydrogels and, in particular, supramolecular hydrogels show promising properties for application in regenerative medicine because of their ability to adapt to the natural environment these materials are brought into. However, only few studies focus on the structure-property relationships in supramol...

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Autores principales: Pape, A. C. H., Bastings, Maartje M. C., Kieltyka, Roxanne E., Wyss, Hans M., Voets, Ilja K., Meijer, E. W., Dankers, Patricia Y. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907858/
https://www.ncbi.nlm.nih.gov/pubmed/24441567
http://dx.doi.org/10.3390/ijms15011096
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author Pape, A. C. H.
Bastings, Maartje M. C.
Kieltyka, Roxanne E.
Wyss, Hans M.
Voets, Ilja K.
Meijer, E. W.
Dankers, Patricia Y. W.
author_facet Pape, A. C. H.
Bastings, Maartje M. C.
Kieltyka, Roxanne E.
Wyss, Hans M.
Voets, Ilja K.
Meijer, E. W.
Dankers, Patricia Y. W.
author_sort Pape, A. C. H.
collection PubMed
description Hydrogels and, in particular, supramolecular hydrogels show promising properties for application in regenerative medicine because of their ability to adapt to the natural environment these materials are brought into. However, only few studies focus on the structure-property relationships in supramolecular hydrogels. Here, we study in detail both the structure and the mechanical properties of such a network, composed of poly(ethylene glycol), end-functionalized with ureido-pyrimidinone fourfold hydrogen bonding units. This network is responsive to triggers such as concentration, temperature and pH. To obtain more insight into the sol-gel transition of the system, both rheology and small-angle X-ray scattering (SAXS) are used. We show that the sol-gel transitions based on these three triggers, as measured by rheology, coincide with the appearance of a structural feature in SAXS. We attribute this feature to the presence of hydrophobic domains where cross-links are formed. These results provide more insight into the mechanism of network formation in these materials, which can be exploited for tailoring their behavior for biomedical applications, where one of the triggers discussed might be used.
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spelling pubmed-39078582014-01-31 Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology Pape, A. C. H. Bastings, Maartje M. C. Kieltyka, Roxanne E. Wyss, Hans M. Voets, Ilja K. Meijer, E. W. Dankers, Patricia Y. W. Int J Mol Sci Article Hydrogels and, in particular, supramolecular hydrogels show promising properties for application in regenerative medicine because of their ability to adapt to the natural environment these materials are brought into. However, only few studies focus on the structure-property relationships in supramolecular hydrogels. Here, we study in detail both the structure and the mechanical properties of such a network, composed of poly(ethylene glycol), end-functionalized with ureido-pyrimidinone fourfold hydrogen bonding units. This network is responsive to triggers such as concentration, temperature and pH. To obtain more insight into the sol-gel transition of the system, both rheology and small-angle X-ray scattering (SAXS) are used. We show that the sol-gel transitions based on these three triggers, as measured by rheology, coincide with the appearance of a structural feature in SAXS. We attribute this feature to the presence of hydrophobic domains where cross-links are formed. These results provide more insight into the mechanism of network formation in these materials, which can be exploited for tailoring their behavior for biomedical applications, where one of the triggers discussed might be used. Molecular Diversity Preservation International (MDPI) 2014-01-16 /pmc/articles/PMC3907858/ /pubmed/24441567 http://dx.doi.org/10.3390/ijms15011096 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Pape, A. C. H.
Bastings, Maartje M. C.
Kieltyka, Roxanne E.
Wyss, Hans M.
Voets, Ilja K.
Meijer, E. W.
Dankers, Patricia Y. W.
Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology
title Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology
title_full Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology
title_fullStr Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology
title_full_unstemmed Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology
title_short Mesoscale Characterization of Supramolecular Transient Networks Using SAXS and Rheology
title_sort mesoscale characterization of supramolecular transient networks using saxs and rheology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907858/
https://www.ncbi.nlm.nih.gov/pubmed/24441567
http://dx.doi.org/10.3390/ijms15011096
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