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Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation
Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating such secondary injury has provided the conceptual basis for neuroprotective treatments. Despite strong experimental data, mo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907865/ https://www.ncbi.nlm.nih.gov/pubmed/24445258 http://dx.doi.org/10.3390/ijms15011216 |
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author | Kabadi, Shruti V. Faden, Alan I. |
author_facet | Kabadi, Shruti V. Faden, Alan I. |
author_sort | Kabadi, Shruti V. |
collection | PubMed |
description | Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating such secondary injury has provided the conceptual basis for neuroprotective treatments. Despite strong experimental data, more than 30 clinical trials of neuroprotection in TBI patients have failed. In part, these failures likely reflect methodological differences between the clinical and animal studies, as well as inadequate pre-clinical evaluation and/or trial design problems. However, recent changes in experimental approach and advances in clinical trial methodology have raised the potential for successful clinical translation. Here we critically analyze the current limitations and translational opportunities for developing successful neuroprotective therapies for TBI. |
format | Online Article Text |
id | pubmed-3907865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-39078652014-01-31 Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation Kabadi, Shruti V. Faden, Alan I. Int J Mol Sci Review Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating such secondary injury has provided the conceptual basis for neuroprotective treatments. Despite strong experimental data, more than 30 clinical trials of neuroprotection in TBI patients have failed. In part, these failures likely reflect methodological differences between the clinical and animal studies, as well as inadequate pre-clinical evaluation and/or trial design problems. However, recent changes in experimental approach and advances in clinical trial methodology have raised the potential for successful clinical translation. Here we critically analyze the current limitations and translational opportunities for developing successful neuroprotective therapies for TBI. Molecular Diversity Preservation International (MDPI) 2014-01-17 /pmc/articles/PMC3907865/ /pubmed/24445258 http://dx.doi.org/10.3390/ijms15011216 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Kabadi, Shruti V. Faden, Alan I. Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation |
title | Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation |
title_full | Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation |
title_fullStr | Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation |
title_full_unstemmed | Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation |
title_short | Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation |
title_sort | neuroprotective strategies for traumatic brain injury: improving clinical translation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907865/ https://www.ncbi.nlm.nih.gov/pubmed/24445258 http://dx.doi.org/10.3390/ijms15011216 |
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