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Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)

One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the ante...

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Autores principales: Giannaccini, Martina, Giannini, Marianna, Calatayud, M. Pilar, Goya, Gerardo F., Cuschieri, Alfred, Dente, Luciana, Raffa, Vittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907888/
https://www.ncbi.nlm.nih.gov/pubmed/24451140
http://dx.doi.org/10.3390/ijms15011590
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author Giannaccini, Martina
Giannini, Marianna
Calatayud, M. Pilar
Goya, Gerardo F.
Cuschieri, Alfred
Dente, Luciana
Raffa, Vittoria
author_facet Giannaccini, Martina
Giannini, Marianna
Calatayud, M. Pilar
Goya, Gerardo F.
Cuschieri, Alfred
Dente, Luciana
Raffa, Vittoria
author_sort Giannaccini, Martina
collection PubMed
description One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the anterior eye chamber, while targeting the posterior chamber is still an open issue. The retina and the retinal pigment epithelium/choroid tissues, located in the posterior eye chamber, are responsible for the majority of blindness both in childhood and adulthood. In the present study, we used magnetic nanoparticles (MNPs) as a nanotool for ocular drug delivery that is capable of specific localization in the retinal pigmented epithelium (RPE) layer. We demonstrate that, following intraocular injection in Xenopus embryos, MNPs localize specifically in RPE where they are retained for several days. The specificity of the localization did not depend on particle size and surface properties of the MNPs used in this work. Moreover, through similar experiments in zebrafish, we demonstrated that the targeting of RPE by the nanoparticles is not specific for the Xenopus species.
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spelling pubmed-39078882014-01-31 Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE) Giannaccini, Martina Giannini, Marianna Calatayud, M. Pilar Goya, Gerardo F. Cuschieri, Alfred Dente, Luciana Raffa, Vittoria Int J Mol Sci Article One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the anterior eye chamber, while targeting the posterior chamber is still an open issue. The retina and the retinal pigment epithelium/choroid tissues, located in the posterior eye chamber, are responsible for the majority of blindness both in childhood and adulthood. In the present study, we used magnetic nanoparticles (MNPs) as a nanotool for ocular drug delivery that is capable of specific localization in the retinal pigmented epithelium (RPE) layer. We demonstrate that, following intraocular injection in Xenopus embryos, MNPs localize specifically in RPE where they are retained for several days. The specificity of the localization did not depend on particle size and surface properties of the MNPs used in this work. Moreover, through similar experiments in zebrafish, we demonstrated that the targeting of RPE by the nanoparticles is not specific for the Xenopus species. Molecular Diversity Preservation International (MDPI) 2014-01-22 /pmc/articles/PMC3907888/ /pubmed/24451140 http://dx.doi.org/10.3390/ijms15011590 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Giannaccini, Martina
Giannini, Marianna
Calatayud, M. Pilar
Goya, Gerardo F.
Cuschieri, Alfred
Dente, Luciana
Raffa, Vittoria
Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
title Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
title_full Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
title_fullStr Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
title_full_unstemmed Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
title_short Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
title_sort magnetic nanoparticles as intraocular drug delivery system to target retinal pigmented epithelium (rpe)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907888/
https://www.ncbi.nlm.nih.gov/pubmed/24451140
http://dx.doi.org/10.3390/ijms15011590
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