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Induced pluripotent stem (iPS) cells offer a powerful new tool for the life sciences

Stem cell biology started with the analysis of somatic stem cells that function to maintain the adult body. We now know that the body is maintained by regeneration of a wide range of cell types, such as skin cells, blood cells and gastrointestinal mucous cells, from somatic stem cells. This regenera...

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Detalles Bibliográficos
Autor principal: Nakamura, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of Stem cells and Regenerative medicine 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908254/
https://www.ncbi.nlm.nih.gov/pubmed/24693054
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author Nakamura, Y
author_facet Nakamura, Y
author_sort Nakamura, Y
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description Stem cell biology started with the analysis of somatic stem cells that function to maintain the adult body. We now know that the body is maintained by regeneration of a wide range of cell types, such as skin cells, blood cells and gastrointestinal mucous cells, from somatic stem cells. This regenerative activity is essential for survival. Regenerative medicine was initiated to identify therapies that support and/or accelerate this natural regenerative ability. For example, bone marrow transplantation is a therapy for reconstituting hematopoiesis from the hematopoietic stem cells present in the donor bone marrow. The successful development of a protocol for obtaining human embryonic stem (ES) cells prompted medical scientists to utilize human ES cells for regenerative medicine. However, use of these cells raises ethical issues as they are derived from human embryos. An alternative approach using ES-like pluripotent stem cells has the considerable advantage that it does not necessitate use of human embryos. Pluripotent stem cells can be induced from terminally differentiated somatic cells by the introduction of only four defined factors. The products of this method are termed “induced pluripotent stem (iPS)” cells. iPS cells have considerable promise as a substitute for ES cells not only for regenerative medicine but also in many other fields. For example, liver and heart cells derived from iPS cells can be used in pharmaceutical research. In addition, iPS cell technology opens new avenues of disease research, for example, by construction of so-called “disease-specific iPS cells” from a patient’s somatic cells.
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spelling pubmed-39082542014-04-01 Induced pluripotent stem (iPS) cells offer a powerful new tool for the life sciences Nakamura, Y J Stem Cells Regen Med Review Article Stem cell biology started with the analysis of somatic stem cells that function to maintain the adult body. We now know that the body is maintained by regeneration of a wide range of cell types, such as skin cells, blood cells and gastrointestinal mucous cells, from somatic stem cells. This regenerative activity is essential for survival. Regenerative medicine was initiated to identify therapies that support and/or accelerate this natural regenerative ability. For example, bone marrow transplantation is a therapy for reconstituting hematopoiesis from the hematopoietic stem cells present in the donor bone marrow. The successful development of a protocol for obtaining human embryonic stem (ES) cells prompted medical scientists to utilize human ES cells for regenerative medicine. However, use of these cells raises ethical issues as they are derived from human embryos. An alternative approach using ES-like pluripotent stem cells has the considerable advantage that it does not necessitate use of human embryos. Pluripotent stem cells can be induced from terminally differentiated somatic cells by the introduction of only four defined factors. The products of this method are termed “induced pluripotent stem (iPS)” cells. iPS cells have considerable promise as a substitute for ES cells not only for regenerative medicine but also in many other fields. For example, liver and heart cells derived from iPS cells can be used in pharmaceutical research. In addition, iPS cell technology opens new avenues of disease research, for example, by construction of so-called “disease-specific iPS cells” from a patient’s somatic cells. Journal of Stem cells and Regenerative medicine 2010-04-05 /pmc/articles/PMC3908254/ /pubmed/24693054 Text en Copyright © 2010 Journal of Stem cells and Regenerative medicine http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nakamura, Y
Induced pluripotent stem (iPS) cells offer a powerful new tool for the life sciences
title Induced pluripotent stem (iPS) cells offer a powerful new tool for the life sciences
title_full Induced pluripotent stem (iPS) cells offer a powerful new tool for the life sciences
title_fullStr Induced pluripotent stem (iPS) cells offer a powerful new tool for the life sciences
title_full_unstemmed Induced pluripotent stem (iPS) cells offer a powerful new tool for the life sciences
title_short Induced pluripotent stem (iPS) cells offer a powerful new tool for the life sciences
title_sort induced pluripotent stem (ips) cells offer a powerful new tool for the life sciences
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908254/
https://www.ncbi.nlm.nih.gov/pubmed/24693054
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