An attenuated mutant of the Rv1747 ATP-binding cassette transporter of Mycobacterium tuberculosis and a mutant of its cognate kinase, PknF, show increased expression of the efflux pump-related iniBAC operon

The ATP-binding cassette transporter Rv1747 is required for the growth of Mycobacterium tuberculosis in mice and in macrophages. Its structure suggests it is an exporter. Rv1747 forms a two-gene operon with pknF coding for the serine/threonine protein kinase PknF, which positively modulates the func...

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Detalles Bibliográficos
Autores principales: Spivey, Vicky L, Whalan, Rachael H, Hirst, Elizabeth M A, Smerdon, Stephen J, Buxton, Roger S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908365/
https://www.ncbi.nlm.nih.gov/pubmed/23915284
http://dx.doi.org/10.1111/1574-6968.12230

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