A critical role for IGF-II in memory consolidation and enhancement

We report that, in the rat, administering insulin-like growth factor II (IGF-II) significantly enhances memory retention and prevents forgetting. Inhibitory avoidance learning leads to an increase in hippocampal expression of IGF-II, which requires the transcription factor CCAAT enhancer binding pro...

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Detalles Bibliográficos
Autores principales: Chen, Dillon Y., Stern, Sarah A., Garcia-Osta, Ana, Saunier-Rebori, Bernadette, Pollonini, Gabriella, Bambah-Mukku, Dhananjay, Blitzer, Robert D., Alberini, Cristina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908455/
https://www.ncbi.nlm.nih.gov/pubmed/21270887
http://dx.doi.org/10.1038/nature09667

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