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Bone necrosis around dental implants: A patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX
Osteonecrosis of the jaw (ONJ) may appear following certain oral surgery procedures in patients treated with oral bisphosphonates (OB). Guidelines for the treatment of these patients were set out in the American Association of Oral and Maxillofacial Surgeons (AAOMS) Position Paper on Bisphosphonate-...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908817/ https://www.ncbi.nlm.nih.gov/pubmed/24558532 http://dx.doi.org/10.4317/jced.50698 |
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author | Flichy-Fernández, A J. González-Lemonnier, S. Balaguer-Martínez, J. Peñarrocha-Oltra, Diego Peñarrocha-Diago, Maria A. Bagán-Sebastián, Jose V. |
author_facet | Flichy-Fernández, A J. González-Lemonnier, S. Balaguer-Martínez, J. Peñarrocha-Oltra, Diego Peñarrocha-Diago, Maria A. Bagán-Sebastián, Jose V. |
author_sort | Flichy-Fernández, A J. |
collection | PubMed |
description | Osteonecrosis of the jaw (ONJ) may appear following certain oral surgery procedures in patients treated with oral bisphosphonates (OB). Guidelines for the treatment of these patients were set out in the American Association of Oral and Maxillofacial Surgeons (AAOMS) Position Paper on Bisphosphonate-Related Osteonecrosis of The Jaws (Position Paper) and Approved by the Board of Trustees in September 2006. For the AAOMS the placement of implants in these patients is not contraindicated. In addition, the serum C-terminal telopeptide bone suppressor marker (CTX) test is available to determine the risk of ONJ. A case is presented of ONJ in a patient with 6 months of OB discontinuation (“drug holiday”) before dental implant placement (following the guidelines of the AAOMS) and with no risk of osteonecrosis according to the serum CTX value (340 pg/ml). The wound healed favorably with complete healing at 7 months. In this case, the serum CTX test must be questioned as to its predictive value of ONJ, and more reliable markers of this risk are needed. Key words:Bisphosphonates, dental implants, bone necrosis, serum CTX. |
format | Online Article Text |
id | pubmed-3908817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39088172014-02-20 Bone necrosis around dental implants: A patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX Flichy-Fernández, A J. González-Lemonnier, S. Balaguer-Martínez, J. Peñarrocha-Oltra, Diego Peñarrocha-Diago, Maria A. Bagán-Sebastián, Jose V. J Clin Exp Dent Case Report Osteonecrosis of the jaw (ONJ) may appear following certain oral surgery procedures in patients treated with oral bisphosphonates (OB). Guidelines for the treatment of these patients were set out in the American Association of Oral and Maxillofacial Surgeons (AAOMS) Position Paper on Bisphosphonate-Related Osteonecrosis of The Jaws (Position Paper) and Approved by the Board of Trustees in September 2006. For the AAOMS the placement of implants in these patients is not contraindicated. In addition, the serum C-terminal telopeptide bone suppressor marker (CTX) test is available to determine the risk of ONJ. A case is presented of ONJ in a patient with 6 months of OB discontinuation (“drug holiday”) before dental implant placement (following the guidelines of the AAOMS) and with no risk of osteonecrosis according to the serum CTX value (340 pg/ml). The wound healed favorably with complete healing at 7 months. In this case, the serum CTX test must be questioned as to its predictive value of ONJ, and more reliable markers of this risk are needed. Key words:Bisphosphonates, dental implants, bone necrosis, serum CTX. Medicina Oral S.L. 2012-02-01 /pmc/articles/PMC3908817/ /pubmed/24558532 http://dx.doi.org/10.4317/jced.50698 Text en Copyright: © 2012 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Flichy-Fernández, A J. González-Lemonnier, S. Balaguer-Martínez, J. Peñarrocha-Oltra, Diego Peñarrocha-Diago, Maria A. Bagán-Sebastián, Jose V. Bone necrosis around dental implants: A patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX |
title | Bone necrosis around dental implants: A patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX |
title_full | Bone necrosis around dental implants: A patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX |
title_fullStr | Bone necrosis around dental implants: A patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX |
title_full_unstemmed | Bone necrosis around dental implants: A patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX |
title_short | Bone necrosis around dental implants: A patient treated with oral bisphosphonates, drug holiday and no risk according to serum CTX |
title_sort | bone necrosis around dental implants: a patient treated with oral bisphosphonates, drug holiday and no risk according to serum ctx |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908817/ https://www.ncbi.nlm.nih.gov/pubmed/24558532 http://dx.doi.org/10.4317/jced.50698 |
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