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Increased circulating obestatin in patients with chronic obstructive pulmonary disease

BACKGROUND: Some peptides, which regulate the metabolic balance, are thought to play important roles in nutritional disorders and systemic inflammation in COPD. Treatment of rats with obestatin decreased body-weight gain. Obestatin was also found to be correlated with inflammation in rheumatoid arth...

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Autores principales: Lei, Yi, Liang, Yasha, Chen, Yifan, Liu, Xiaojing, Liao, Xiaoyang, Luo, Fengming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908911/
https://www.ncbi.nlm.nih.gov/pubmed/24468053
http://dx.doi.org/10.1186/2049-6958-9-5
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author Lei, Yi
Liang, Yasha
Chen, Yifan
Liu, Xiaojing
Liao, Xiaoyang
Luo, Fengming
author_facet Lei, Yi
Liang, Yasha
Chen, Yifan
Liu, Xiaojing
Liao, Xiaoyang
Luo, Fengming
author_sort Lei, Yi
collection PubMed
description BACKGROUND: Some peptides, which regulate the metabolic balance, are thought to play important roles in nutritional disorders and systemic inflammation in COPD. Treatment of rats with obestatin decreased body-weight gain. Obestatin was also found to be correlated with inflammation in rheumatoid arthritis. The aims of this study were to investigate the level of circulating obestatin in COPD and to analyze the relationship among obestatin and nutritional status, and systemic inflammation. METHODS: 32 COPD patients with BMI less than 20 kg/m(2) and 22 normal controls were included. Body composition was estimated using “foot-to-foot” BIA technology. Circulating obestatin was determined with enzyme-linked immunosorbent assay. Pulmonary function, TNF-α and C reactive protein were also measured. RESULTS: The level of circulating obestatin was higher in COPD with underweight than that in normal control (5562.75 ± 3435.43 pg/ml in COPD, 3663.90 ± 2313.95 pg/ml in controls, p = 0.028). BMI, Waist circumference, hip circumference, bodyFAT and FAT% in COPD group were lower than those in normal control. Positive correlation was found among circulating C reactive protein, TNF-α and obestatin. There was no significant correlation among BMI, pulmonary function and obestatin. CONCLUSIONS: This study shows that circulating obestatin is higher in underweight COPD patients, and positively correlated to systemic inflammation, but not to nutritional status.
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spelling pubmed-39089112014-02-01 Increased circulating obestatin in patients with chronic obstructive pulmonary disease Lei, Yi Liang, Yasha Chen, Yifan Liu, Xiaojing Liao, Xiaoyang Luo, Fengming Multidiscip Respir Med Original Research Article BACKGROUND: Some peptides, which regulate the metabolic balance, are thought to play important roles in nutritional disorders and systemic inflammation in COPD. Treatment of rats with obestatin decreased body-weight gain. Obestatin was also found to be correlated with inflammation in rheumatoid arthritis. The aims of this study were to investigate the level of circulating obestatin in COPD and to analyze the relationship among obestatin and nutritional status, and systemic inflammation. METHODS: 32 COPD patients with BMI less than 20 kg/m(2) and 22 normal controls were included. Body composition was estimated using “foot-to-foot” BIA technology. Circulating obestatin was determined with enzyme-linked immunosorbent assay. Pulmonary function, TNF-α and C reactive protein were also measured. RESULTS: The level of circulating obestatin was higher in COPD with underweight than that in normal control (5562.75 ± 3435.43 pg/ml in COPD, 3663.90 ± 2313.95 pg/ml in controls, p = 0.028). BMI, Waist circumference, hip circumference, bodyFAT and FAT% in COPD group were lower than those in normal control. Positive correlation was found among circulating C reactive protein, TNF-α and obestatin. There was no significant correlation among BMI, pulmonary function and obestatin. CONCLUSIONS: This study shows that circulating obestatin is higher in underweight COPD patients, and positively correlated to systemic inflammation, but not to nutritional status. BioMed Central 2014-01-28 /pmc/articles/PMC3908911/ /pubmed/24468053 http://dx.doi.org/10.1186/2049-6958-9-5 Text en Copyright © 2014 Lei et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Research Article
Lei, Yi
Liang, Yasha
Chen, Yifan
Liu, Xiaojing
Liao, Xiaoyang
Luo, Fengming
Increased circulating obestatin in patients with chronic obstructive pulmonary disease
title Increased circulating obestatin in patients with chronic obstructive pulmonary disease
title_full Increased circulating obestatin in patients with chronic obstructive pulmonary disease
title_fullStr Increased circulating obestatin in patients with chronic obstructive pulmonary disease
title_full_unstemmed Increased circulating obestatin in patients with chronic obstructive pulmonary disease
title_short Increased circulating obestatin in patients with chronic obstructive pulmonary disease
title_sort increased circulating obestatin in patients with chronic obstructive pulmonary disease
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908911/
https://www.ncbi.nlm.nih.gov/pubmed/24468053
http://dx.doi.org/10.1186/2049-6958-9-5
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