Novel Pharmacologic Targeting of Tight Junctions and Focal Adhesions in Prostate Cancer Cells

Cancer cell resistance to anoikis driven by aberrant signaling sustained by the tumor microenvironment confers high invasive potential and therapeutic resistance. We recently generated a novel lead quinazoline-based Doxazosin® derivative, DZ-50, which impairs tumor growth and metastasis via anoikis....

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Detalles Bibliográficos
Autores principales: Hensley, Patrick J., Desiniotis, Andreas, Wang, Chi, Stromberg, Arnold, Chen, Ching-Shih, Kyprianou, Natasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908921/
https://www.ncbi.nlm.nih.gov/pubmed/24497940
http://dx.doi.org/10.1371/journal.pone.0086238

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