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CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12

Recently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3). In this study, we aimed to investigate the expressi...

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Autores principales: Melo, Rita de Cássia Carvalho, Longhini, Ana Leda, Bigarella, Carolina Louzão, Baratti, Mariana Ozello, Traina, Fabiola, Favaro, Patrícia, de Melo Campos, Paula, Saad, Sara Teresinha Olalla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908922/
https://www.ncbi.nlm.nih.gov/pubmed/24497931
http://dx.doi.org/10.1371/journal.pone.0085926
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author Melo, Rita de Cássia Carvalho
Longhini, Ana Leda
Bigarella, Carolina Louzão
Baratti, Mariana Ozello
Traina, Fabiola
Favaro, Patrícia
de Melo Campos, Paula
Saad, Sara Teresinha Olalla
author_facet Melo, Rita de Cássia Carvalho
Longhini, Ana Leda
Bigarella, Carolina Louzão
Baratti, Mariana Ozello
Traina, Fabiola
Favaro, Patrícia
de Melo Campos, Paula
Saad, Sara Teresinha Olalla
author_sort Melo, Rita de Cássia Carvalho
collection PubMed
description Recently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3). In this study, we aimed to investigate the expression of CXCR7 in leukemic cells, as well as its participation in CXCL12 response. Interesting, we clearly demonstrated that CXCR7 is highly expressed in acute lymphoid leukemic cells compared with myeloid or normal hematopoietic cells and that CXCR7 contributed to T-acute lymphoid leukemic cell migration induced by CXCL12. Moreover, we showed that the cellular location of CXCR7 varied among T-lymphoid cells and this finding may be related to their migration capacity. Finally, we hypothesized that CXCR7 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells.
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spelling pubmed-39089222014-02-04 CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12 Melo, Rita de Cássia Carvalho Longhini, Ana Leda Bigarella, Carolina Louzão Baratti, Mariana Ozello Traina, Fabiola Favaro, Patrícia de Melo Campos, Paula Saad, Sara Teresinha Olalla PLoS One Research Article Recently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3). In this study, we aimed to investigate the expression of CXCR7 in leukemic cells, as well as its participation in CXCL12 response. Interesting, we clearly demonstrated that CXCR7 is highly expressed in acute lymphoid leukemic cells compared with myeloid or normal hematopoietic cells and that CXCR7 contributed to T-acute lymphoid leukemic cell migration induced by CXCL12. Moreover, we showed that the cellular location of CXCR7 varied among T-lymphoid cells and this finding may be related to their migration capacity. Finally, we hypothesized that CXCR7 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells. Public Library of Science 2014-01-31 /pmc/articles/PMC3908922/ /pubmed/24497931 http://dx.doi.org/10.1371/journal.pone.0085926 Text en © 2014 Melo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Melo, Rita de Cássia Carvalho
Longhini, Ana Leda
Bigarella, Carolina Louzão
Baratti, Mariana Ozello
Traina, Fabiola
Favaro, Patrícia
de Melo Campos, Paula
Saad, Sara Teresinha Olalla
CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12
title CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12
title_full CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12
title_fullStr CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12
title_full_unstemmed CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12
title_short CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12
title_sort cxcr7 is highly expressed in acute lymphoblastic leukemia and potentiates cxcr4 response to cxcl12
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908922/
https://www.ncbi.nlm.nih.gov/pubmed/24497931
http://dx.doi.org/10.1371/journal.pone.0085926
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