Changes in Cx43 and Na(V)1.5 Expression Precede the Occurrence of Substantial Fibrosis in Calcineurin-Induced Murine Cardiac Hypertrophy

In mice, the calcium-dependent phosphatase calcineurin A (CnA) induces a transcriptional pathway leading to pathological cardiac hypertrophy. Interestingly, induction of CnA has been frequently noticed in human hypertrophic and failing hearts. Independently, the arrhythmia vulnerability of such hear...

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Detalles Bibliográficos
Autores principales: Fontes, Magda S. C., Raaijmakers, Antonia J. A., van Doorn, Tessa, Kok, Bart, Nieuwenhuis, Sylvia, van der Nagel, Roel, Vos, Marc A., de Boer, Teun P., van Rijen, Harold V. M., Bierhuizen, Marti F. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909068/
https://www.ncbi.nlm.nih.gov/pubmed/24498049
http://dx.doi.org/10.1371/journal.pone.0087226

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