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Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase
Phosphite dehydrogenase (PTDH) catalyzes the NAD(+)-dependent oxidation of phosphite to phosphate. This reaction requires the deprotonation of a water nucleophile for attack on phosphite. A crystal structure was recently solved that identified Arg301 as a potential base given its proximity and orien...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909101/ https://www.ncbi.nlm.nih.gov/pubmed/24498026 http://dx.doi.org/10.1371/journal.pone.0087134 |