Acquired Deficiency of A20 Results in Rapid Apoptosis, Systemic Inflammation, and Abnormal Hematopoietic Stem Cell Function

A20 is a negative regulator of NF-κB, and mutational loss of A20 expression is involved in the pathogenesis of autoimmune diseases and B-cell lymphomas. To clarify the role of A20 in adult hematopoiesis, we generated conditional A20 knockout mice (A20(flox/flox)) and crossed them with Mx–1Cre (MxCre...

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Detalles Bibliográficos
Autores principales: Nagamachi, Akiko, Nakata, Yuichiro, Ueda, Takeshi, Yamasaki, Norimasa, Ebihara, Yasuhiro, Tsuji, Kohichiro, Honda, Zen-ichiro, Takubo, Keiyo, Suda, Toshio, Oda, Hideaki, Inaba, Toshiya, Honda, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909109/
https://www.ncbi.nlm.nih.gov/pubmed/24498102
http://dx.doi.org/10.1371/journal.pone.0087425

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