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Enhanced Virus-Specific CD8(+) T Cell Responses by Listeria monocytogenes-Infected Dendritic Cells in the Context of Tim-3 Blockade

In this study, we engineered Listeria monocytogens (Lm) by deleting the LmΔactA/ΔinlB virulence determinants and inserting HCV-NS5B consensus antigens to develop a therapeutic vaccine against hepatitis C virus (HCV) infection. We tested this recombinant Lm-HCV vaccine in triggering of innate and ada...

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Detalles Bibliográficos
Autores principales:	Ma, Cheng J., Ren, Jun P., Li, Guang Y., Wu, Xiao Y., Brockstedt, Dirk G., Lauer, Peter, Moorman, Jonathan P., Yao, Zhi Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909257/ https://www.ncbi.nlm.nih.gov/pubmed/24498204 http://dx.doi.org/10.1371/journal.pone.0087821

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