Cargando…
Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns
Multivariate analytical routines have become increasingly popular in the study of cerebral function in health and in disease states. Spatial covariance analysis of functional neuroimaging data has been used to identify and validate characteristic topographies associated with specific brain disorders...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909315/ https://www.ncbi.nlm.nih.gov/pubmed/24498250 http://dx.doi.org/10.1371/journal.pone.0088119 |
_version_ | 1782301827426942976 |
---|---|
author | Ko, Ji Hyun Spetsieris, Phoebe Ma, Yilong Dhawan, Vijay Eidelberg, David |
author_facet | Ko, Ji Hyun Spetsieris, Phoebe Ma, Yilong Dhawan, Vijay Eidelberg, David |
author_sort | Ko, Ji Hyun |
collection | PubMed |
description | Multivariate analytical routines have become increasingly popular in the study of cerebral function in health and in disease states. Spatial covariance analysis of functional neuroimaging data has been used to identify and validate characteristic topographies associated with specific brain disorders. Voxel-wise correlations can be used to assess similarities and differences that exist between covariance topographies. While the magnitude of the resulting topographical correlations is critical, statistical significance can be difficult to determine in the setting of large data vectors (comprised of over 100,000 voxel weights) and substantial autocorrelation effects. Here, we propose a novel method to determine the p-value of such correlations using pseudo-random network simulations. |
format | Online Article Text |
id | pubmed-3909315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39093152014-02-04 Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns Ko, Ji Hyun Spetsieris, Phoebe Ma, Yilong Dhawan, Vijay Eidelberg, David PLoS One Research Article Multivariate analytical routines have become increasingly popular in the study of cerebral function in health and in disease states. Spatial covariance analysis of functional neuroimaging data has been used to identify and validate characteristic topographies associated with specific brain disorders. Voxel-wise correlations can be used to assess similarities and differences that exist between covariance topographies. While the magnitude of the resulting topographical correlations is critical, statistical significance can be difficult to determine in the setting of large data vectors (comprised of over 100,000 voxel weights) and substantial autocorrelation effects. Here, we propose a novel method to determine the p-value of such correlations using pseudo-random network simulations. Public Library of Science 2014-01-31 /pmc/articles/PMC3909315/ /pubmed/24498250 http://dx.doi.org/10.1371/journal.pone.0088119 Text en © 2014 Ko et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Ko, Ji Hyun Spetsieris, Phoebe Ma, Yilong Dhawan, Vijay Eidelberg, David Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns |
title | Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns |
title_full | Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns |
title_fullStr | Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns |
title_full_unstemmed | Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns |
title_short | Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns |
title_sort | quantifying significance of topographical similarities of disease-related brain metabolic patterns |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909315/ https://www.ncbi.nlm.nih.gov/pubmed/24498250 http://dx.doi.org/10.1371/journal.pone.0088119 |
work_keys_str_mv | AT kojihyun quantifyingsignificanceoftopographicalsimilaritiesofdiseaserelatedbrainmetabolicpatterns AT spetsierisphoebe quantifyingsignificanceoftopographicalsimilaritiesofdiseaserelatedbrainmetabolicpatterns AT mayilong quantifyingsignificanceoftopographicalsimilaritiesofdiseaserelatedbrainmetabolicpatterns AT dhawanvijay quantifyingsignificanceoftopographicalsimilaritiesofdiseaserelatedbrainmetabolicpatterns AT eidelbergdavid quantifyingsignificanceoftopographicalsimilaritiesofdiseaserelatedbrainmetabolicpatterns |