Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disorder caused by mutations in the dystrophin gene that result in the absence of the membrane-stabilising protein dystrophin. Dystrophic muscle fibres are susceptible to injury and degeneration, and impaired mu...

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Autores principales: Swiderski, Kristy, Todorov, Michelle, Gehrig, Stefan M, Naim, Timur, Chee, Annabel, Stapleton, David I, Koopman, René, Lynch, Gordon S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909382/
https://www.ncbi.nlm.nih.gov/pubmed/24476069
http://dx.doi.org/10.1186/1755-1536-7-1

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