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Molecular markers of cell adhesion in ameloblastomas. An update

Ameloblastoma is the most common odontogenic tumor of epithelial origin, and though it is of a benign nature, it frequently infiltrates the bone, has a high rate of recurrence and could potentially become malignant. Cellular adhesion potentially plays an important role in the manifestation of these...

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Autores principales: González-González, Rogelio, Molina-Frechero, Nelly, Damian-Matsumura, Pablo, Bologna-Molina, Ronell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909437/
https://www.ncbi.nlm.nih.gov/pubmed/23986011
http://dx.doi.org/10.4317/medoral.19071
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author González-González, Rogelio
Molina-Frechero, Nelly
Damian-Matsumura, Pablo
Bologna-Molina, Ronell
author_facet González-González, Rogelio
Molina-Frechero, Nelly
Damian-Matsumura, Pablo
Bologna-Molina, Ronell
author_sort González-González, Rogelio
collection PubMed
description Ameloblastoma is the most common odontogenic tumor of epithelial origin, and though it is of a benign nature, it frequently infiltrates the bone, has a high rate of recurrence and could potentially become malignant. Cellular adhesion potentially plays an important role in the manifestation of these characteristics and in the tumor biology of ameloblastomas. Losses of cell-cell and extracellular matrix adhesion and cohesion are among the first events that occur in the invasion and growth of tumors of epithelial origin. The present review includes a description of the molecules that are involved in cell adhesion as reported for various types of ameloblastomas and discusses the possible roles of these molecules in the biological behaviors of this odontogenic tumor. Knowledge of the complex mechanisms in which these molecules play a role is critical for the research and discovery of future therapeutic targets. Key words:Ameloblastoma, cellular adhesion, molecular markers, cell-cell adhesion, extracellular matrix-cell adhesion.
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spelling pubmed-39094372014-02-10 Molecular markers of cell adhesion in ameloblastomas. An update González-González, Rogelio Molina-Frechero, Nelly Damian-Matsumura, Pablo Bologna-Molina, Ronell Med Oral Patol Oral Cir Bucal Review Ameloblastoma is the most common odontogenic tumor of epithelial origin, and though it is of a benign nature, it frequently infiltrates the bone, has a high rate of recurrence and could potentially become malignant. Cellular adhesion potentially plays an important role in the manifestation of these characteristics and in the tumor biology of ameloblastomas. Losses of cell-cell and extracellular matrix adhesion and cohesion are among the first events that occur in the invasion and growth of tumors of epithelial origin. The present review includes a description of the molecules that are involved in cell adhesion as reported for various types of ameloblastomas and discusses the possible roles of these molecules in the biological behaviors of this odontogenic tumor. Knowledge of the complex mechanisms in which these molecules play a role is critical for the research and discovery of future therapeutic targets. Key words:Ameloblastoma, cellular adhesion, molecular markers, cell-cell adhesion, extracellular matrix-cell adhesion. Medicina Oral S.L. 2014-01 2013-08-29 /pmc/articles/PMC3909437/ /pubmed/23986011 http://dx.doi.org/10.4317/medoral.19071 Text en Copyright: © 2014 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
González-González, Rogelio
Molina-Frechero, Nelly
Damian-Matsumura, Pablo
Bologna-Molina, Ronell
Molecular markers of cell adhesion in ameloblastomas. An update
title Molecular markers of cell adhesion in ameloblastomas. An update
title_full Molecular markers of cell adhesion in ameloblastomas. An update
title_fullStr Molecular markers of cell adhesion in ameloblastomas. An update
title_full_unstemmed Molecular markers of cell adhesion in ameloblastomas. An update
title_short Molecular markers of cell adhesion in ameloblastomas. An update
title_sort molecular markers of cell adhesion in ameloblastomas. an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909437/
https://www.ncbi.nlm.nih.gov/pubmed/23986011
http://dx.doi.org/10.4317/medoral.19071
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