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Predictors for delayed encephalopathy following acute carbon monoxide poisoning

BACKGROUND: In Japan, many carbon monoxide (CO) poisoning cases are transported to emergency settings, making treatment and prognostic assessment an urgent task. However, there is currently no reliable means to predict whether “delayed neuropsychiatric sequelae (DNS)” will develop after acute CO poi...

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Autores principales: Kudo, Kaoru, Otsuka, Kotaro, Yagi, Junko, Sanjo, Katsumi, Koizumi, Noritaka, Koeda, Atsuhiko, Umetsu, Miki Yokota, Yoshioka, Yasuhito, Mizugai, Ayumi, Mita, Toshinari, Shiga, Yu, Koizumi, Fumito, Nakamura, Hikaru, Sakai, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909505/
https://www.ncbi.nlm.nih.gov/pubmed/24484081
http://dx.doi.org/10.1186/1471-227X-14-3
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author Kudo, Kaoru
Otsuka, Kotaro
Yagi, Junko
Sanjo, Katsumi
Koizumi, Noritaka
Koeda, Atsuhiko
Umetsu, Miki Yokota
Yoshioka, Yasuhito
Mizugai, Ayumi
Mita, Toshinari
Shiga, Yu
Koizumi, Fumito
Nakamura, Hikaru
Sakai, Akio
author_facet Kudo, Kaoru
Otsuka, Kotaro
Yagi, Junko
Sanjo, Katsumi
Koizumi, Noritaka
Koeda, Atsuhiko
Umetsu, Miki Yokota
Yoshioka, Yasuhito
Mizugai, Ayumi
Mita, Toshinari
Shiga, Yu
Koizumi, Fumito
Nakamura, Hikaru
Sakai, Akio
author_sort Kudo, Kaoru
collection PubMed
description BACKGROUND: In Japan, many carbon monoxide (CO) poisoning cases are transported to emergency settings, making treatment and prognostic assessment an urgent task. However, there is currently no reliable means to predict whether “delayed neuropsychiatric sequelae (DNS)” will develop after acute CO poisoning. This study is intended to find out risk factors for the development of DNS and to characterize the clinical course following the development of DNS in acute CO poisoning cases. METHODS: This is a retrospective cohort study of 79 consecutive patients treated at a single institution for CO poisoning. This study included 79 cases of acute CO poisoning admitted to our emergency department after attempted suicide, who were divided into two groups consisting of 13 cases who developed DNS and 66 cases who did not. The two groups were compared and analyzed in terms of clinical symptoms, laboratory findings, etc. RESULTS: Predictors for the development of DNS following acute CO poisoning included: serious consciousness disturbance at emergency admission; head CT findings indicating hypoxic encephalopathy; hematology findings including high creatine kinase, creatine kinase-MB and lactate dehydrogenase levels; and low Global Assessment Scale scores. The clinical course of the DNS-developing cases was characterized by prolonged hospital stay and a larger number of hyperbaric oxygen (HBO) therapy sessions. CONCLUSION: In patients with the characteristics identified in this study, administration of HBO therapy should be proactively considered after informing their family, at initial stage, of the risk of developing DNS, and at least 5 weeks’ follow-up to watch for the development of DNS is considered necessary.
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spelling pubmed-39095052014-02-02 Predictors for delayed encephalopathy following acute carbon monoxide poisoning Kudo, Kaoru Otsuka, Kotaro Yagi, Junko Sanjo, Katsumi Koizumi, Noritaka Koeda, Atsuhiko Umetsu, Miki Yokota Yoshioka, Yasuhito Mizugai, Ayumi Mita, Toshinari Shiga, Yu Koizumi, Fumito Nakamura, Hikaru Sakai, Akio BMC Emerg Med Research Article BACKGROUND: In Japan, many carbon monoxide (CO) poisoning cases are transported to emergency settings, making treatment and prognostic assessment an urgent task. However, there is currently no reliable means to predict whether “delayed neuropsychiatric sequelae (DNS)” will develop after acute CO poisoning. This study is intended to find out risk factors for the development of DNS and to characterize the clinical course following the development of DNS in acute CO poisoning cases. METHODS: This is a retrospective cohort study of 79 consecutive patients treated at a single institution for CO poisoning. This study included 79 cases of acute CO poisoning admitted to our emergency department after attempted suicide, who were divided into two groups consisting of 13 cases who developed DNS and 66 cases who did not. The two groups were compared and analyzed in terms of clinical symptoms, laboratory findings, etc. RESULTS: Predictors for the development of DNS following acute CO poisoning included: serious consciousness disturbance at emergency admission; head CT findings indicating hypoxic encephalopathy; hematology findings including high creatine kinase, creatine kinase-MB and lactate dehydrogenase levels; and low Global Assessment Scale scores. The clinical course of the DNS-developing cases was characterized by prolonged hospital stay and a larger number of hyperbaric oxygen (HBO) therapy sessions. CONCLUSION: In patients with the characteristics identified in this study, administration of HBO therapy should be proactively considered after informing their family, at initial stage, of the risk of developing DNS, and at least 5 weeks’ follow-up to watch for the development of DNS is considered necessary. BioMed Central 2014-01-31 /pmc/articles/PMC3909505/ /pubmed/24484081 http://dx.doi.org/10.1186/1471-227X-14-3 Text en Copyright © 2014 Kudo et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kudo, Kaoru
Otsuka, Kotaro
Yagi, Junko
Sanjo, Katsumi
Koizumi, Noritaka
Koeda, Atsuhiko
Umetsu, Miki Yokota
Yoshioka, Yasuhito
Mizugai, Ayumi
Mita, Toshinari
Shiga, Yu
Koizumi, Fumito
Nakamura, Hikaru
Sakai, Akio
Predictors for delayed encephalopathy following acute carbon monoxide poisoning
title Predictors for delayed encephalopathy following acute carbon monoxide poisoning
title_full Predictors for delayed encephalopathy following acute carbon monoxide poisoning
title_fullStr Predictors for delayed encephalopathy following acute carbon monoxide poisoning
title_full_unstemmed Predictors for delayed encephalopathy following acute carbon monoxide poisoning
title_short Predictors for delayed encephalopathy following acute carbon monoxide poisoning
title_sort predictors for delayed encephalopathy following acute carbon monoxide poisoning
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909505/
https://www.ncbi.nlm.nih.gov/pubmed/24484081
http://dx.doi.org/10.1186/1471-227X-14-3
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