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Predictors for delayed encephalopathy following acute carbon monoxide poisoning
BACKGROUND: In Japan, many carbon monoxide (CO) poisoning cases are transported to emergency settings, making treatment and prognostic assessment an urgent task. However, there is currently no reliable means to predict whether “delayed neuropsychiatric sequelae (DNS)” will develop after acute CO poi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909505/ https://www.ncbi.nlm.nih.gov/pubmed/24484081 http://dx.doi.org/10.1186/1471-227X-14-3 |
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author | Kudo, Kaoru Otsuka, Kotaro Yagi, Junko Sanjo, Katsumi Koizumi, Noritaka Koeda, Atsuhiko Umetsu, Miki Yokota Yoshioka, Yasuhito Mizugai, Ayumi Mita, Toshinari Shiga, Yu Koizumi, Fumito Nakamura, Hikaru Sakai, Akio |
author_facet | Kudo, Kaoru Otsuka, Kotaro Yagi, Junko Sanjo, Katsumi Koizumi, Noritaka Koeda, Atsuhiko Umetsu, Miki Yokota Yoshioka, Yasuhito Mizugai, Ayumi Mita, Toshinari Shiga, Yu Koizumi, Fumito Nakamura, Hikaru Sakai, Akio |
author_sort | Kudo, Kaoru |
collection | PubMed |
description | BACKGROUND: In Japan, many carbon monoxide (CO) poisoning cases are transported to emergency settings, making treatment and prognostic assessment an urgent task. However, there is currently no reliable means to predict whether “delayed neuropsychiatric sequelae (DNS)” will develop after acute CO poisoning. This study is intended to find out risk factors for the development of DNS and to characterize the clinical course following the development of DNS in acute CO poisoning cases. METHODS: This is a retrospective cohort study of 79 consecutive patients treated at a single institution for CO poisoning. This study included 79 cases of acute CO poisoning admitted to our emergency department after attempted suicide, who were divided into two groups consisting of 13 cases who developed DNS and 66 cases who did not. The two groups were compared and analyzed in terms of clinical symptoms, laboratory findings, etc. RESULTS: Predictors for the development of DNS following acute CO poisoning included: serious consciousness disturbance at emergency admission; head CT findings indicating hypoxic encephalopathy; hematology findings including high creatine kinase, creatine kinase-MB and lactate dehydrogenase levels; and low Global Assessment Scale scores. The clinical course of the DNS-developing cases was characterized by prolonged hospital stay and a larger number of hyperbaric oxygen (HBO) therapy sessions. CONCLUSION: In patients with the characteristics identified in this study, administration of HBO therapy should be proactively considered after informing their family, at initial stage, of the risk of developing DNS, and at least 5 weeks’ follow-up to watch for the development of DNS is considered necessary. |
format | Online Article Text |
id | pubmed-3909505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39095052014-02-02 Predictors for delayed encephalopathy following acute carbon monoxide poisoning Kudo, Kaoru Otsuka, Kotaro Yagi, Junko Sanjo, Katsumi Koizumi, Noritaka Koeda, Atsuhiko Umetsu, Miki Yokota Yoshioka, Yasuhito Mizugai, Ayumi Mita, Toshinari Shiga, Yu Koizumi, Fumito Nakamura, Hikaru Sakai, Akio BMC Emerg Med Research Article BACKGROUND: In Japan, many carbon monoxide (CO) poisoning cases are transported to emergency settings, making treatment and prognostic assessment an urgent task. However, there is currently no reliable means to predict whether “delayed neuropsychiatric sequelae (DNS)” will develop after acute CO poisoning. This study is intended to find out risk factors for the development of DNS and to characterize the clinical course following the development of DNS in acute CO poisoning cases. METHODS: This is a retrospective cohort study of 79 consecutive patients treated at a single institution for CO poisoning. This study included 79 cases of acute CO poisoning admitted to our emergency department after attempted suicide, who were divided into two groups consisting of 13 cases who developed DNS and 66 cases who did not. The two groups were compared and analyzed in terms of clinical symptoms, laboratory findings, etc. RESULTS: Predictors for the development of DNS following acute CO poisoning included: serious consciousness disturbance at emergency admission; head CT findings indicating hypoxic encephalopathy; hematology findings including high creatine kinase, creatine kinase-MB and lactate dehydrogenase levels; and low Global Assessment Scale scores. The clinical course of the DNS-developing cases was characterized by prolonged hospital stay and a larger number of hyperbaric oxygen (HBO) therapy sessions. CONCLUSION: In patients with the characteristics identified in this study, administration of HBO therapy should be proactively considered after informing their family, at initial stage, of the risk of developing DNS, and at least 5 weeks’ follow-up to watch for the development of DNS is considered necessary. BioMed Central 2014-01-31 /pmc/articles/PMC3909505/ /pubmed/24484081 http://dx.doi.org/10.1186/1471-227X-14-3 Text en Copyright © 2014 Kudo et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kudo, Kaoru Otsuka, Kotaro Yagi, Junko Sanjo, Katsumi Koizumi, Noritaka Koeda, Atsuhiko Umetsu, Miki Yokota Yoshioka, Yasuhito Mizugai, Ayumi Mita, Toshinari Shiga, Yu Koizumi, Fumito Nakamura, Hikaru Sakai, Akio Predictors for delayed encephalopathy following acute carbon monoxide poisoning |
title | Predictors for delayed encephalopathy following acute carbon monoxide poisoning |
title_full | Predictors for delayed encephalopathy following acute carbon monoxide poisoning |
title_fullStr | Predictors for delayed encephalopathy following acute carbon monoxide poisoning |
title_full_unstemmed | Predictors for delayed encephalopathy following acute carbon monoxide poisoning |
title_short | Predictors for delayed encephalopathy following acute carbon monoxide poisoning |
title_sort | predictors for delayed encephalopathy following acute carbon monoxide poisoning |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909505/ https://www.ncbi.nlm.nih.gov/pubmed/24484081 http://dx.doi.org/10.1186/1471-227X-14-3 |
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