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TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity
We have recently described a novel modular targeting platform for T cell recruitment that not only efficiently replaces but also is superior to conventional T cell-engaging bispecific antibodies as it allows for the flexible targeting of several antigens and the delivery of co-stimulatory ligands to...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909541/ https://www.ncbi.nlm.nih.gov/pubmed/24498554 http://dx.doi.org/10.4161/onci.26770 |
| _version_ | 1782301865616080896 |
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| author | Cartellieri, Marc Arndt, Claudia Feldmann, Anja von Bonin, Malte Ewen, Eva-Maria Koristka, Stefanie Michalk, Irene Stamova, Slava Berndt, Nicole Gocht, Anne Bornhäuser, Martin Ehninger, Gerhard Schmitz, Marc Bachmann, Michael |
| author_facet | Cartellieri, Marc Arndt, Claudia Feldmann, Anja von Bonin, Malte Ewen, Eva-Maria Koristka, Stefanie Michalk, Irene Stamova, Slava Berndt, Nicole Gocht, Anne Bornhäuser, Martin Ehninger, Gerhard Schmitz, Marc Bachmann, Michael |
| author_sort | Cartellieri, Marc |
| collection | PubMed |
| description | We have recently described a novel modular targeting platform for T cell recruitment that not only efficiently replaces but also is superior to conventional T cell-engaging bispecific antibodies as it allows for the flexible targeting of several antigens and the delivery of co-stimulatory ligands to malignant lesions, thereby enhancing the antitumor potential of redirected T cells. |
| format | Online Article Text |
| id | pubmed-3909541 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-39095412014-02-04 TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity Cartellieri, Marc Arndt, Claudia Feldmann, Anja von Bonin, Malte Ewen, Eva-Maria Koristka, Stefanie Michalk, Irene Stamova, Slava Berndt, Nicole Gocht, Anne Bornhäuser, Martin Ehninger, Gerhard Schmitz, Marc Bachmann, Michael Oncoimmunology Author's View We have recently described a novel modular targeting platform for T cell recruitment that not only efficiently replaces but also is superior to conventional T cell-engaging bispecific antibodies as it allows for the flexible targeting of several antigens and the delivery of co-stimulatory ligands to malignant lesions, thereby enhancing the antitumor potential of redirected T cells. Landes Bioscience 2013-12-01 2013-10-22 /pmc/articles/PMC3909541/ /pubmed/24498554 http://dx.doi.org/10.4161/onci.26770 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Cartellieri, Marc Arndt, Claudia Feldmann, Anja von Bonin, Malte Ewen, Eva-Maria Koristka, Stefanie Michalk, Irene Stamova, Slava Berndt, Nicole Gocht, Anne Bornhäuser, Martin Ehninger, Gerhard Schmitz, Marc Bachmann, Michael TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity |
| title | TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity |
| title_full | TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity |
| title_fullStr | TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity |
| title_full_unstemmed | TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity |
| title_short | TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity |
| title_sort | tcr/cd3 activation and co-stimulation combined in one t cell retargeting system improve anti-tumor immunity |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909541/ https://www.ncbi.nlm.nih.gov/pubmed/24498554 http://dx.doi.org/10.4161/onci.26770 |
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