Cargando…

Emerging roles of mistletoes in malignancy management

Mistletoes are a group of obligate plant semi-parasites in the order Santalales. These clumps of plants growing on a wide range of host plants have been traditionally regarded as medicinal repositories. However, current scientific discoveries have validated their health potentials like never before....

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Seema, Panda, Suryakanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909578/
https://www.ncbi.nlm.nih.gov/pubmed/28324460
http://dx.doi.org/10.1007/s13205-013-0124-6
_version_ 1782301870181580800
author Patel, Seema
Panda, Suryakanta
author_facet Patel, Seema
Panda, Suryakanta
author_sort Patel, Seema
collection PubMed
description Mistletoes are a group of obligate plant semi-parasites in the order Santalales. These clumps of plants growing on a wide range of host plants have been traditionally regarded as medicinal repositories. However, current scientific discoveries have validated their health potentials like never before. Their extracts containing alkaloids, viscotoxins, lectins, and polysaccharides have been evidenced to possess a myriad biological potentials including cancer inhibition. Mistletoes have emerged as promising alternative therapy against colon, oral, lung, and pancreas cancers. The plant extracts bolster immunity, delay tumour initiation and progression, kill malignant tumours, stabilize DNA, alleviate side effects of chemotherapeutics, improve the lifespan, and coping ability of cancer patients and survivors. A range of proprietary formulations viz. Iscador, Eurixor, Helixor, Lektinol, Isorel, Iscucin, Abnoba-viscum and recombinant lectin ML-1 are already being commercialized. This review presents an informative account on the recent developments in mistletoe-mediated cancer management. The underlying mechanisms, possibilities and limitations in cancer therapeutic development are outlined for kindling both researcher and public interest.
format Online
Article
Text
id pubmed-3909578
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-39095782014-02-06 Emerging roles of mistletoes in malignancy management Patel, Seema Panda, Suryakanta 3 Biotech Review Article Mistletoes are a group of obligate plant semi-parasites in the order Santalales. These clumps of plants growing on a wide range of host plants have been traditionally regarded as medicinal repositories. However, current scientific discoveries have validated their health potentials like never before. Their extracts containing alkaloids, viscotoxins, lectins, and polysaccharides have been evidenced to possess a myriad biological potentials including cancer inhibition. Mistletoes have emerged as promising alternative therapy against colon, oral, lung, and pancreas cancers. The plant extracts bolster immunity, delay tumour initiation and progression, kill malignant tumours, stabilize DNA, alleviate side effects of chemotherapeutics, improve the lifespan, and coping ability of cancer patients and survivors. A range of proprietary formulations viz. Iscador, Eurixor, Helixor, Lektinol, Isorel, Iscucin, Abnoba-viscum and recombinant lectin ML-1 are already being commercialized. This review presents an informative account on the recent developments in mistletoe-mediated cancer management. The underlying mechanisms, possibilities and limitations in cancer therapeutic development are outlined for kindling both researcher and public interest. Springer Berlin Heidelberg 2013-03-07 2014-02 /pmc/articles/PMC3909578/ /pubmed/28324460 http://dx.doi.org/10.1007/s13205-013-0124-6 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review Article
Patel, Seema
Panda, Suryakanta
Emerging roles of mistletoes in malignancy management
title Emerging roles of mistletoes in malignancy management
title_full Emerging roles of mistletoes in malignancy management
title_fullStr Emerging roles of mistletoes in malignancy management
title_full_unstemmed Emerging roles of mistletoes in malignancy management
title_short Emerging roles of mistletoes in malignancy management
title_sort emerging roles of mistletoes in malignancy management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909578/
https://www.ncbi.nlm.nih.gov/pubmed/28324460
http://dx.doi.org/10.1007/s13205-013-0124-6
work_keys_str_mv AT patelseema emergingrolesofmistletoesinmalignancymanagement
AT pandasuryakanta emergingrolesofmistletoesinmalignancymanagement