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Emerging roles of mistletoes in malignancy management
Mistletoes are a group of obligate plant semi-parasites in the order Santalales. These clumps of plants growing on a wide range of host plants have been traditionally regarded as medicinal repositories. However, current scientific discoveries have validated their health potentials like never before....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909578/ https://www.ncbi.nlm.nih.gov/pubmed/28324460 http://dx.doi.org/10.1007/s13205-013-0124-6 |
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author | Patel, Seema Panda, Suryakanta |
author_facet | Patel, Seema Panda, Suryakanta |
author_sort | Patel, Seema |
collection | PubMed |
description | Mistletoes are a group of obligate plant semi-parasites in the order Santalales. These clumps of plants growing on a wide range of host plants have been traditionally regarded as medicinal repositories. However, current scientific discoveries have validated their health potentials like never before. Their extracts containing alkaloids, viscotoxins, lectins, and polysaccharides have been evidenced to possess a myriad biological potentials including cancer inhibition. Mistletoes have emerged as promising alternative therapy against colon, oral, lung, and pancreas cancers. The plant extracts bolster immunity, delay tumour initiation and progression, kill malignant tumours, stabilize DNA, alleviate side effects of chemotherapeutics, improve the lifespan, and coping ability of cancer patients and survivors. A range of proprietary formulations viz. Iscador, Eurixor, Helixor, Lektinol, Isorel, Iscucin, Abnoba-viscum and recombinant lectin ML-1 are already being commercialized. This review presents an informative account on the recent developments in mistletoe-mediated cancer management. The underlying mechanisms, possibilities and limitations in cancer therapeutic development are outlined for kindling both researcher and public interest. |
format | Online Article Text |
id | pubmed-3909578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-39095782014-02-06 Emerging roles of mistletoes in malignancy management Patel, Seema Panda, Suryakanta 3 Biotech Review Article Mistletoes are a group of obligate plant semi-parasites in the order Santalales. These clumps of plants growing on a wide range of host plants have been traditionally regarded as medicinal repositories. However, current scientific discoveries have validated their health potentials like never before. Their extracts containing alkaloids, viscotoxins, lectins, and polysaccharides have been evidenced to possess a myriad biological potentials including cancer inhibition. Mistletoes have emerged as promising alternative therapy against colon, oral, lung, and pancreas cancers. The plant extracts bolster immunity, delay tumour initiation and progression, kill malignant tumours, stabilize DNA, alleviate side effects of chemotherapeutics, improve the lifespan, and coping ability of cancer patients and survivors. A range of proprietary formulations viz. Iscador, Eurixor, Helixor, Lektinol, Isorel, Iscucin, Abnoba-viscum and recombinant lectin ML-1 are already being commercialized. This review presents an informative account on the recent developments in mistletoe-mediated cancer management. The underlying mechanisms, possibilities and limitations in cancer therapeutic development are outlined for kindling both researcher and public interest. Springer Berlin Heidelberg 2013-03-07 2014-02 /pmc/articles/PMC3909578/ /pubmed/28324460 http://dx.doi.org/10.1007/s13205-013-0124-6 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Article Patel, Seema Panda, Suryakanta Emerging roles of mistletoes in malignancy management |
title | Emerging roles of mistletoes in malignancy management |
title_full | Emerging roles of mistletoes in malignancy management |
title_fullStr | Emerging roles of mistletoes in malignancy management |
title_full_unstemmed | Emerging roles of mistletoes in malignancy management |
title_short | Emerging roles of mistletoes in malignancy management |
title_sort | emerging roles of mistletoes in malignancy management |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909578/ https://www.ncbi.nlm.nih.gov/pubmed/28324460 http://dx.doi.org/10.1007/s13205-013-0124-6 |
work_keys_str_mv | AT patelseema emergingrolesofmistletoesinmalignancymanagement AT pandasuryakanta emergingrolesofmistletoesinmalignancymanagement |