Cargando…

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate()

Green tea is rich in polyphenol flavonoids including catechins. Epigallocatechin 3-gallate (EGCG) is the most abundant and potent green tea catechin. EGCG has been extensively studied for its beneficial health effects as a nutriceutical agent. Based upon its chemical structure, EGCG is often classif...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hae-Suk, Quon, Michael J., Kim, Jeong-a
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909779/
https://www.ncbi.nlm.nih.gov/pubmed/24494192
http://dx.doi.org/10.1016/j.redox.2013.12.022
_version_ 1782301886804656128
author Kim, Hae-Suk
Quon, Michael J.
Kim, Jeong-a
author_facet Kim, Hae-Suk
Quon, Michael J.
Kim, Jeong-a
author_sort Kim, Hae-Suk
collection PubMed
description Green tea is rich in polyphenol flavonoids including catechins. Epigallocatechin 3-gallate (EGCG) is the most abundant and potent green tea catechin. EGCG has been extensively studied for its beneficial health effects as a nutriceutical agent. Based upon its chemical structure, EGCG is often classified as an antioxidant. However, treatment of cells with EGCG results in production of hydrogen peroxide and hydroxyl radicals in the presence of Fe (III). Thus, EGCG functions as a pro-oxidant in some cellular contexts. Recent investigations have revealed many other direct actions of EGCG that are independent from anti-oxidative mechanisms. In this review, we discuss these novel molecular mechanisms of action for EGCG. In particular, EGCG directly interacts with proteins and phospholipids in the plasma membrane and regulates signal transduction pathways, transcription factors, DNA methylation, mitochondrial function, and autophagy to exert many of its beneficial biological actions.
format Online
Article
Text
id pubmed-3909779
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-39097792014-02-03 New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate() Kim, Hae-Suk Quon, Michael J. Kim, Jeong-a Redox Biol Mini Review Green tea is rich in polyphenol flavonoids including catechins. Epigallocatechin 3-gallate (EGCG) is the most abundant and potent green tea catechin. EGCG has been extensively studied for its beneficial health effects as a nutriceutical agent. Based upon its chemical structure, EGCG is often classified as an antioxidant. However, treatment of cells with EGCG results in production of hydrogen peroxide and hydroxyl radicals in the presence of Fe (III). Thus, EGCG functions as a pro-oxidant in some cellular contexts. Recent investigations have revealed many other direct actions of EGCG that are independent from anti-oxidative mechanisms. In this review, we discuss these novel molecular mechanisms of action for EGCG. In particular, EGCG directly interacts with proteins and phospholipids in the plasma membrane and regulates signal transduction pathways, transcription factors, DNA methylation, mitochondrial function, and autophagy to exert many of its beneficial biological actions. Elsevier 2014-01-10 /pmc/articles/PMC3909779/ /pubmed/24494192 http://dx.doi.org/10.1016/j.redox.2013.12.022 Text en © 2014 The Authors https://creativecommons.org/licenses/by-nc-sa/3.0/This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License (https://creativecommons.org/licenses/by-nc-sa/3.0/) .
spellingShingle Mini Review
Kim, Hae-Suk
Quon, Michael J.
Kim, Jeong-a
New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate()
title New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate()
title_full New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate()
title_fullStr New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate()
title_full_unstemmed New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate()
title_short New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate()
title_sort new insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate()
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909779/
https://www.ncbi.nlm.nih.gov/pubmed/24494192
http://dx.doi.org/10.1016/j.redox.2013.12.022
work_keys_str_mv AT kimhaesuk newinsightsintothemechanismsofpolyphenolsbeyondantioxidantpropertieslessonsfromthegreenteapolyphenolepigallocatechin3gallate
AT quonmichaelj newinsightsintothemechanismsofpolyphenolsbeyondantioxidantpropertieslessonsfromthegreenteapolyphenolepigallocatechin3gallate
AT kimjeonga newinsightsintothemechanismsofpolyphenolsbeyondantioxidantpropertieslessonsfromthegreenteapolyphenolepigallocatechin3gallate