Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples

High resolution yttrium-90 ((90)Y) imaging of post-radioembolization microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability. However, reconstructed (90)Y PET/CT images have hig...

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Autores principales: Kao, Yung Hsiang, Tan, Andrew E. H., Lo, Richard H. G., Tay, Kiang Hiong, Tan, Bien Soo, Chow, Pierce K. H., Ng, David C. E., Goh, Anthony S. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910080/
https://www.ncbi.nlm.nih.gov/pubmed/24551594
http://dx.doi.org/10.3389/fonc.2014.00011
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author Kao, Yung Hsiang
Tan, Andrew E. H.
Lo, Richard H. G.
Tay, Kiang Hiong
Tan, Bien Soo
Chow, Pierce K. H.
Ng, David C. E.
Goh, Anthony S. W.
author_facet Kao, Yung Hsiang
Tan, Andrew E. H.
Lo, Richard H. G.
Tay, Kiang Hiong
Tan, Bien Soo
Chow, Pierce K. H.
Ng, David C. E.
Goh, Anthony S. W.
author_sort Kao, Yung Hsiang
collection PubMed
description High resolution yttrium-90 ((90)Y) imaging of post-radioembolization microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability. However, reconstructed (90)Y PET/CT images have high background noise, making non-target activity detection technically challenging. This educational article describes our image assessment technique for non-target activity detection by (90)Y PET/CT, which qualitatively overcomes the problem of background noise. We present selected case examples of non-target activity in untargeted liver, stomach, gallbladder, chest wall, and kidney, supported by angiography and (90)Y bremsstrahlung single-photon emission computed tomography with integrated computed tomography (SPECT/CT) or technetium-99m macroaggregated albumin SPECT/CT.
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spelling pubmed-39100802014-02-18 Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples Kao, Yung Hsiang Tan, Andrew E. H. Lo, Richard H. G. Tay, Kiang Hiong Tan, Bien Soo Chow, Pierce K. H. Ng, David C. E. Goh, Anthony S. W. Front Oncol Oncology High resolution yttrium-90 ((90)Y) imaging of post-radioembolization microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability. However, reconstructed (90)Y PET/CT images have high background noise, making non-target activity detection technically challenging. This educational article describes our image assessment technique for non-target activity detection by (90)Y PET/CT, which qualitatively overcomes the problem of background noise. We present selected case examples of non-target activity in untargeted liver, stomach, gallbladder, chest wall, and kidney, supported by angiography and (90)Y bremsstrahlung single-photon emission computed tomography with integrated computed tomography (SPECT/CT) or technetium-99m macroaggregated albumin SPECT/CT. Frontiers Media S.A. 2014-02-03 /pmc/articles/PMC3910080/ /pubmed/24551594 http://dx.doi.org/10.3389/fonc.2014.00011 Text en Copyright © 2014 Kao, Tan, Lo, Tay, Tan, Chow, Ng and Goh. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Kao, Yung Hsiang
Tan, Andrew E. H.
Lo, Richard H. G.
Tay, Kiang Hiong
Tan, Bien Soo
Chow, Pierce K. H.
Ng, David C. E.
Goh, Anthony S. W.
Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_full Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_fullStr Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_full_unstemmed Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_short Non-Target Activity Detection by Post-Radioembolization Yttrium-90 PET/CT: Image Assessment Technique and Case Examples
title_sort non-target activity detection by post-radioembolization yttrium-90 pet/ct: image assessment technique and case examples
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910080/
https://www.ncbi.nlm.nih.gov/pubmed/24551594
http://dx.doi.org/10.3389/fonc.2014.00011
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