The structural mechanism of KCNH-channel regulation by the eag domain

The KCNH voltage-dependent potassium channels (ether-á-go-go, EAG; EAG-related gene, ERG; EAG-like channels, ELK) are important regulators of cellular excitability(1-3) and have key roles in diseases such as cardiac long QT syndrome type 2 (LQT2)(4), epilepsy(5), schizophrenia(6) and cancer(7). The...

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Detalles Bibliográficos
Autores principales: Haitin, Yoni, Carlson, Anne E., Zagotta, William N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910112/
https://www.ncbi.nlm.nih.gov/pubmed/23975098
http://dx.doi.org/10.1038/nature12487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910112/
https://www.ncbi.nlm.nih.gov/pubmed/23975098
http://dx.doi.org/10.1038/nature12487

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