Cargando…

Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions

The calcineurin/nuclear factor of activated T cells (NFATs) signaling pathway plays a central role in T cell mediated adaptive immune responses, but a number of recent studies demonstrated that calcineurin/NFAT signaling also plays a key role in the control of the innate immune response by myeloid c...

Descripción completa

Detalles Bibliográficos
Autores principales: Vandewalle, Alain, Tourneur, Emilie, Bens, Marcelle, Chassin, Cécilia, Werts, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910266/
https://www.ncbi.nlm.nih.gov/pubmed/24479879
http://dx.doi.org/10.1186/1478-811X-12-8
_version_ 1782301957063442432
author Vandewalle, Alain
Tourneur, Emilie
Bens, Marcelle
Chassin, Cécilia
Werts, Catherine
author_facet Vandewalle, Alain
Tourneur, Emilie
Bens, Marcelle
Chassin, Cécilia
Werts, Catherine
author_sort Vandewalle, Alain
collection PubMed
description The calcineurin/nuclear factor of activated T cells (NFATs) signaling pathway plays a central role in T cell mediated adaptive immune responses, but a number of recent studies demonstrated that calcineurin/NFAT signaling also plays a key role in the control of the innate immune response by myeloid cells. Calcineurin inhibitors, such as cyclosporine A (CsA) and tacrolimus (FK506), are commonly used in organ transplantation to prevent graft rejection and in a variety of immune diseases. These immunosuppressive drugs have adverse effects and significantly increase host’s susceptibility towards bacterial or fungal infections. Recent studies highlighted the role of NFAT signaling in fungal infection and in the control of the pattern recognition receptor nucleotide-binding oligomerization domain-containing protein 1 (NOD1), which predominantly senses invasive Gram-negative bacteria and mediates neutrophil phagocytic functions. This review summarises some of the current knowledge concerning the role of NFAT signaling in the innate immune response and the recent advances on NFAT-dependent inhibition of NOD1-mediated innate immune response caused by CsA, which may contribute to sensitizing transplant recipients to bacterial infection.
format Online
Article
Text
id pubmed-3910266
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-39102662014-02-04 Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions Vandewalle, Alain Tourneur, Emilie Bens, Marcelle Chassin, Cécilia Werts, Catherine Cell Commun Signal Review The calcineurin/nuclear factor of activated T cells (NFATs) signaling pathway plays a central role in T cell mediated adaptive immune responses, but a number of recent studies demonstrated that calcineurin/NFAT signaling also plays a key role in the control of the innate immune response by myeloid cells. Calcineurin inhibitors, such as cyclosporine A (CsA) and tacrolimus (FK506), are commonly used in organ transplantation to prevent graft rejection and in a variety of immune diseases. These immunosuppressive drugs have adverse effects and significantly increase host’s susceptibility towards bacterial or fungal infections. Recent studies highlighted the role of NFAT signaling in fungal infection and in the control of the pattern recognition receptor nucleotide-binding oligomerization domain-containing protein 1 (NOD1), which predominantly senses invasive Gram-negative bacteria and mediates neutrophil phagocytic functions. This review summarises some of the current knowledge concerning the role of NFAT signaling in the innate immune response and the recent advances on NFAT-dependent inhibition of NOD1-mediated innate immune response caused by CsA, which may contribute to sensitizing transplant recipients to bacterial infection. BioMed Central 2014-01-30 /pmc/articles/PMC3910266/ /pubmed/24479879 http://dx.doi.org/10.1186/1478-811X-12-8 Text en Copyright © 2014 Vandewalle et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Vandewalle, Alain
Tourneur, Emilie
Bens, Marcelle
Chassin, Cécilia
Werts, Catherine
Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions
title Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions
title_full Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions
title_fullStr Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions
title_full_unstemmed Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions
title_short Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions
title_sort calcineurin/nfat signaling and innate host defence: a role for nod1-mediated phagocytic functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910266/
https://www.ncbi.nlm.nih.gov/pubmed/24479879
http://dx.doi.org/10.1186/1478-811X-12-8
work_keys_str_mv AT vandewallealain calcineurinnfatsignalingandinnatehostdefencearolefornod1mediatedphagocyticfunctions
AT tourneuremilie calcineurinnfatsignalingandinnatehostdefencearolefornod1mediatedphagocyticfunctions
AT bensmarcelle calcineurinnfatsignalingandinnatehostdefencearolefornod1mediatedphagocyticfunctions
AT chassincecilia calcineurinnfatsignalingandinnatehostdefencearolefornod1mediatedphagocyticfunctions
AT wertscatherine calcineurinnfatsignalingandinnatehostdefencearolefornod1mediatedphagocyticfunctions