The Role of MIF in Type 1 and Type 2 Diabetes Mellitus

Autoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types...

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Detalles Bibliográficos
Autores principales: Sánchez-Zamora, Yuriko I., Rodriguez-Sosa, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910331/
https://www.ncbi.nlm.nih.gov/pubmed/24527464
http://dx.doi.org/10.1155/2014/804519
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author Sánchez-Zamora, Yuriko I.
Rodriguez-Sosa, Miriam
author_facet Sánchez-Zamora, Yuriko I.
Rodriguez-Sosa, Miriam
author_sort Sánchez-Zamora, Yuriko I.
collection PubMed
description Autoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types of diabetes; therefore, understanding the role of MIF could affect our understanding of the autoimmune or inflammatory responses that influence diabetic pathology. This review highlights our current knowledge about the involvement of MIF in both types of diabetes in the clinical environment and in experimental disease models.
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spelling pubmed-39103312014-02-13 The Role of MIF in Type 1 and Type 2 Diabetes Mellitus Sánchez-Zamora, Yuriko I. Rodriguez-Sosa, Miriam J Diabetes Res Review Article Autoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types of diabetes; therefore, understanding the role of MIF could affect our understanding of the autoimmune or inflammatory responses that influence diabetic pathology. This review highlights our current knowledge about the involvement of MIF in both types of diabetes in the clinical environment and in experimental disease models. Hindawi Publishing Corporation 2014 2014-01-02 /pmc/articles/PMC3910331/ /pubmed/24527464 http://dx.doi.org/10.1155/2014/804519 Text en Copyright © 2014 Y. I. Sánchez-Zamora and M. Rodriguez-Sosa. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sánchez-Zamora, Yuriko I.
Rodriguez-Sosa, Miriam
The Role of MIF in Type 1 and Type 2 Diabetes Mellitus
title The Role of MIF in Type 1 and Type 2 Diabetes Mellitus
title_full The Role of MIF in Type 1 and Type 2 Diabetes Mellitus
title_fullStr The Role of MIF in Type 1 and Type 2 Diabetes Mellitus
title_full_unstemmed The Role of MIF in Type 1 and Type 2 Diabetes Mellitus
title_short The Role of MIF in Type 1 and Type 2 Diabetes Mellitus
title_sort role of mif in type 1 and type 2 diabetes mellitus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910331/
https://www.ncbi.nlm.nih.gov/pubmed/24527464
http://dx.doi.org/10.1155/2014/804519
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