Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma

Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291 cancer-free adult controls of European ancest...

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Detalles Bibliográficos
Autores principales: Savage, Sharon A., Mirabello, Lisa, Wang, Zhaoming, Gastier-Foster, Julie M., Gorlick, Richard, Khanna, Chand, Flanagan, Adrienne M., Tirabosco, Roberto, Andrulis, Irene L., Wunder, Jay S., Gokgoz, Nalan, Patiño-Garcia, Ana, Sierrasesúmaga, Luis, Lecanda, Fernando, Kurucu, Nilgün, Ilhan, Inci Ergurhan, Sari, Neriman, Serra, Massimo, Hattinger, Claudia, Picci, Piero, Spector, Logan, Barkauskas, Donald A., Marina, Neyssa, de Toledo, Silvia Regina Caminada, Petrilli, Antonio S., Amary, Maria Fernanda, Halai, Dina, Thomas, David M., Douglass, Chester, Meltzer, Paul S., Jacobs, Kevin, Chung, Charles C., Berndt, Sonja I., Purdue, Mark P., Caporaso, Neil E., Tucker, Margaret, Rothman, Nathaniel, Landi, Maria Teresa, Silverman, Debra T., Kraft, Peter, Hunter, David J., Malats, Nuria, Kogevinas, Manolis, Wacholder, Sholom, Troisi, Rebecca, Helman, Lee, Fraumeni, Joseph F., Yeager, Meredith, Hoover, Robert N., Chanock, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910497/
https://www.ncbi.nlm.nih.gov/pubmed/23727862
http://dx.doi.org/10.1038/ng.2645
Descripción
Sumario:Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: rs1906953 at 6p21.3, in the glutamate receptor metabotropic 4 [GRM4] gene (P = 8.1 ×10(-9)), and rs7591996 and rs10208273 in a gene desert on 2p25.2 (P = 1.0 ×10(-8) and 2.9 ×10(-7)). These two susceptibility loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.

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