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Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma
Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291 cancer-free adult controls of European ancest...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910497/ https://www.ncbi.nlm.nih.gov/pubmed/23727862 http://dx.doi.org/10.1038/ng.2645 |
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| author | Savage, Sharon A. Mirabello, Lisa Wang, Zhaoming Gastier-Foster, Julie M. Gorlick, Richard Khanna, Chand Flanagan, Adrienne M. Tirabosco, Roberto Andrulis, Irene L. Wunder, Jay S. Gokgoz, Nalan Patiño-Garcia, Ana Sierrasesúmaga, Luis Lecanda, Fernando Kurucu, Nilgün Ilhan, Inci Ergurhan Sari, Neriman Serra, Massimo Hattinger, Claudia Picci, Piero Spector, Logan Barkauskas, Donald A. Marina, Neyssa de Toledo, Silvia Regina Caminada Petrilli, Antonio S. Amary, Maria Fernanda Halai, Dina Thomas, David M. Douglass, Chester Meltzer, Paul S. Jacobs, Kevin Chung, Charles C. Berndt, Sonja I. Purdue, Mark P. Caporaso, Neil E. Tucker, Margaret Rothman, Nathaniel Landi, Maria Teresa Silverman, Debra T. Kraft, Peter Hunter, David J. Malats, Nuria Kogevinas, Manolis Wacholder, Sholom Troisi, Rebecca Helman, Lee Fraumeni, Joseph F. Yeager, Meredith Hoover, Robert N. Chanock, Stephen J. |
| author_facet | Savage, Sharon A. Mirabello, Lisa Wang, Zhaoming Gastier-Foster, Julie M. Gorlick, Richard Khanna, Chand Flanagan, Adrienne M. Tirabosco, Roberto Andrulis, Irene L. Wunder, Jay S. Gokgoz, Nalan Patiño-Garcia, Ana Sierrasesúmaga, Luis Lecanda, Fernando Kurucu, Nilgün Ilhan, Inci Ergurhan Sari, Neriman Serra, Massimo Hattinger, Claudia Picci, Piero Spector, Logan Barkauskas, Donald A. Marina, Neyssa de Toledo, Silvia Regina Caminada Petrilli, Antonio S. Amary, Maria Fernanda Halai, Dina Thomas, David M. Douglass, Chester Meltzer, Paul S. Jacobs, Kevin Chung, Charles C. Berndt, Sonja I. Purdue, Mark P. Caporaso, Neil E. Tucker, Margaret Rothman, Nathaniel Landi, Maria Teresa Silverman, Debra T. Kraft, Peter Hunter, David J. Malats, Nuria Kogevinas, Manolis Wacholder, Sholom Troisi, Rebecca Helman, Lee Fraumeni, Joseph F. Yeager, Meredith Hoover, Robert N. Chanock, Stephen J. |
| author_sort | Savage, Sharon A. |
| collection | PubMed |
| description | Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: rs1906953 at 6p21.3, in the glutamate receptor metabotropic 4 [GRM4] gene (P = 8.1 ×10(-9)), and rs7591996 and rs10208273 in a gene desert on 2p25.2 (P = 1.0 ×10(-8) and 2.9 ×10(-7)). These two susceptibility loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma. |
| format | Online Article Text |
| id | pubmed-3910497 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-39104972014-02-03 Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma Savage, Sharon A. Mirabello, Lisa Wang, Zhaoming Gastier-Foster, Julie M. Gorlick, Richard Khanna, Chand Flanagan, Adrienne M. Tirabosco, Roberto Andrulis, Irene L. Wunder, Jay S. Gokgoz, Nalan Patiño-Garcia, Ana Sierrasesúmaga, Luis Lecanda, Fernando Kurucu, Nilgün Ilhan, Inci Ergurhan Sari, Neriman Serra, Massimo Hattinger, Claudia Picci, Piero Spector, Logan Barkauskas, Donald A. Marina, Neyssa de Toledo, Silvia Regina Caminada Petrilli, Antonio S. Amary, Maria Fernanda Halai, Dina Thomas, David M. Douglass, Chester Meltzer, Paul S. Jacobs, Kevin Chung, Charles C. Berndt, Sonja I. Purdue, Mark P. Caporaso, Neil E. Tucker, Margaret Rothman, Nathaniel Landi, Maria Teresa Silverman, Debra T. Kraft, Peter Hunter, David J. Malats, Nuria Kogevinas, Manolis Wacholder, Sholom Troisi, Rebecca Helman, Lee Fraumeni, Joseph F. Yeager, Meredith Hoover, Robert N. Chanock, Stephen J. Nat Genet Article Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: rs1906953 at 6p21.3, in the glutamate receptor metabotropic 4 [GRM4] gene (P = 8.1 ×10(-9)), and rs7591996 and rs10208273 in a gene desert on 2p25.2 (P = 1.0 ×10(-8) and 2.9 ×10(-7)). These two susceptibility loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma. 2013-06-02 2013-07 /pmc/articles/PMC3910497/ /pubmed/23727862 http://dx.doi.org/10.1038/ng.2645 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Savage, Sharon A. Mirabello, Lisa Wang, Zhaoming Gastier-Foster, Julie M. Gorlick, Richard Khanna, Chand Flanagan, Adrienne M. Tirabosco, Roberto Andrulis, Irene L. Wunder, Jay S. Gokgoz, Nalan Patiño-Garcia, Ana Sierrasesúmaga, Luis Lecanda, Fernando Kurucu, Nilgün Ilhan, Inci Ergurhan Sari, Neriman Serra, Massimo Hattinger, Claudia Picci, Piero Spector, Logan Barkauskas, Donald A. Marina, Neyssa de Toledo, Silvia Regina Caminada Petrilli, Antonio S. Amary, Maria Fernanda Halai, Dina Thomas, David M. Douglass, Chester Meltzer, Paul S. Jacobs, Kevin Chung, Charles C. Berndt, Sonja I. Purdue, Mark P. Caporaso, Neil E. Tucker, Margaret Rothman, Nathaniel Landi, Maria Teresa Silverman, Debra T. Kraft, Peter Hunter, David J. Malats, Nuria Kogevinas, Manolis Wacholder, Sholom Troisi, Rebecca Helman, Lee Fraumeni, Joseph F. Yeager, Meredith Hoover, Robert N. Chanock, Stephen J. Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma |
| title | Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma |
| title_full | Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma |
| title_fullStr | Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma |
| title_full_unstemmed | Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma |
| title_short | Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma |
| title_sort | genome-wide association study identifies two susceptibility loci for osteosarcoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910497/ https://www.ncbi.nlm.nih.gov/pubmed/23727862 http://dx.doi.org/10.1038/ng.2645 |
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