The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway

BACKGROUND: The nuclear export of unspliced and partially spliced HIV-1 mRNA is mediated by the recognition of a leucine-rich nuclear export signal (NES) in the HIV Rev protein by the host protein CRM1/Exportin1. This makes the CRM1-Rev complex an attractive target for the development of new antivir...

Descripción completa

Detalles Bibliográficos
Autores principales: Fleta-Soriano, Eric, Martinez, Javier P, Hinkelmann, Bettina, Gerth, Klaus, Washausen, Peter, Diez, Juana, Frank, Ronald, Sasse, Florenz, Meyerhans, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910686/
https://www.ncbi.nlm.nih.gov/pubmed/24475978
http://dx.doi.org/10.1186/1475-2859-13-17

Ejemplares similares

Ejemplares similares