Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence

We determined the comparative activity of SMT19969 (SMT) against 162 strains representing 35 well-characterized Clostridium species in clusters I to XIX and 13 Clostridium species that had no 16S rRNA match. SMT MICs ranged from 0.06 to >512 μg/ml and were not species related. SMT might have less...

Descripción completa

Detalles Bibliográficos
Autores principales: Goldstein, Ellie J. C., Citron, Diane M., Tyrrell, Kerin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910813/
https://www.ncbi.nlm.nih.gov/pubmed/24247123
http://dx.doi.org/10.1128/AAC.02184-13
_version_ 1782301998381531136
author Goldstein, Ellie J. C.
Citron, Diane M.
Tyrrell, Kerin L.
author_facet Goldstein, Ellie J. C.
Citron, Diane M.
Tyrrell, Kerin L.
author_sort Goldstein, Ellie J. C.
collection PubMed
description We determined the comparative activity of SMT19969 (SMT) against 162 strains representing 35 well-characterized Clostridium species in clusters I to XIX and 13 Clostridium species that had no 16S rRNA match. SMT MICs ranged from 0.06 to >512 μg/ml and were not species related. SMT might have less impact on normal gut microbiota than other Clostridium difficile infection (CDI) antimicrobials.
format Online
Article
Text
id pubmed-3910813
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-39108132014-02-07 Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence Goldstein, Ellie J. C. Citron, Diane M. Tyrrell, Kerin L. Antimicrob Agents Chemother Susceptibility We determined the comparative activity of SMT19969 (SMT) against 162 strains representing 35 well-characterized Clostridium species in clusters I to XIX and 13 Clostridium species that had no 16S rRNA match. SMT MICs ranged from 0.06 to >512 μg/ml and were not species related. SMT might have less impact on normal gut microbiota than other Clostridium difficile infection (CDI) antimicrobials. American Society for Microbiology 2014-02 /pmc/articles/PMC3910813/ /pubmed/24247123 http://dx.doi.org/10.1128/AAC.02184-13 Text en Copyright © 2014 Goldstein et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Susceptibility
Goldstein, Ellie J. C.
Citron, Diane M.
Tyrrell, Kerin L.
Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence
title Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence
title_full Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence
title_fullStr Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence
title_full_unstemmed Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence
title_short Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence
title_sort comparative in vitro activities of smt19969, a new antimicrobial agent, against 162 strains from 35 less frequently recovered intestinal clostridium species: implications for clostridium difficile recurrence
topic Susceptibility
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910813/
https://www.ncbi.nlm.nih.gov/pubmed/24247123
http://dx.doi.org/10.1128/AAC.02184-13
work_keys_str_mv AT goldsteinelliejc comparativeinvitroactivitiesofsmt19969anewantimicrobialagentagainst162strainsfrom35lessfrequentlyrecoveredintestinalclostridiumspeciesimplicationsforclostridiumdifficilerecurrence
AT citrondianem comparativeinvitroactivitiesofsmt19969anewantimicrobialagentagainst162strainsfrom35lessfrequentlyrecoveredintestinalclostridiumspeciesimplicationsforclostridiumdifficilerecurrence
AT tyrrellkerinl comparativeinvitroactivitiesofsmt19969anewantimicrobialagentagainst162strainsfrom35lessfrequentlyrecoveredintestinalclostridiumspeciesimplicationsforclostridiumdifficilerecurrence

Ejemplares similares