Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection

The Chlamydia trachomatis plasmid is a virulence factor. Plasmid copy number, C. trachomatis load and disease severity were assessed in a treatment-naive population where trachoma is hyperendemic. By using droplet digital PCR, plasmid copy number was found to be stable (median, 5.34 [range, 1 to 18]...

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Detalles Bibliográficos
Autores principales: Last, Anna R., Roberts, Chrissy h., Cassama, Eunice, Nabicassa, Meno, Molina-Gonzalez, Sandra, Burr, Sarah E., Mabey, David C. W., Bailey, Robin L., Holland, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Chlamydiology and Rickettsiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911420/
https://www.ncbi.nlm.nih.gov/pubmed/24197878
http://dx.doi.org/10.1128/JCM.02618-13
Descripción
Sumario:The Chlamydia trachomatis plasmid is a virulence factor. Plasmid copy number, C. trachomatis load and disease severity were assessed in a treatment-naive population where trachoma is hyperendemic. By using droplet digital PCR, plasmid copy number was found to be stable (median, 5.34 [range, 1 to 18]) and there were no associations with C. trachomatis load or disease severity.

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