Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection

The Chlamydia trachomatis plasmid is a virulence factor. Plasmid copy number, C. trachomatis load and disease severity were assessed in a treatment-naive population where trachoma is hyperendemic. By using droplet digital PCR, plasmid copy number was found to be stable (median, 5.34 [range, 1 to 18]...

Descripción completa

Detalles Bibliográficos
Autores principales: Last, Anna R., Roberts, Chrissy h., Cassama, Eunice, Nabicassa, Meno, Molina-Gonzalez, Sandra, Burr, Sarah E., Mabey, David C. W., Bailey, Robin L., Holland, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Chlamydiology and Rickettsiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911420/
https://www.ncbi.nlm.nih.gov/pubmed/24197878
http://dx.doi.org/10.1128/JCM.02618-13
_version_ 1782301999718465536
author Last, Anna R.
Roberts, Chrissy h.
Cassama, Eunice
Nabicassa, Meno
Molina-Gonzalez, Sandra
Burr, Sarah E.
Mabey, David C. W.
Bailey, Robin L.
Holland, Martin J.
author_facet Last, Anna R.
Roberts, Chrissy h.
Cassama, Eunice
Nabicassa, Meno
Molina-Gonzalez, Sandra
Burr, Sarah E.
Mabey, David C. W.
Bailey, Robin L.
Holland, Martin J.
author_sort Last, Anna R.
collection PubMed
description The Chlamydia trachomatis plasmid is a virulence factor. Plasmid copy number, C. trachomatis load and disease severity were assessed in a treatment-naive population where trachoma is hyperendemic. By using droplet digital PCR, plasmid copy number was found to be stable (median, 5.34 [range, 1 to 18]) and there were no associations with C. trachomatis load or disease severity.
format Online
Article
Text
id pubmed-3911420
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-39114202014-02-13 Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection Last, Anna R. Roberts, Chrissy h. Cassama, Eunice Nabicassa, Meno Molina-Gonzalez, Sandra Burr, Sarah E. Mabey, David C. W. Bailey, Robin L. Holland, Martin J. J Clin Microbiol Chlamydiology and Rickettsiology The Chlamydia trachomatis plasmid is a virulence factor. Plasmid copy number, C. trachomatis load and disease severity were assessed in a treatment-naive population where trachoma is hyperendemic. By using droplet digital PCR, plasmid copy number was found to be stable (median, 5.34 [range, 1 to 18]) and there were no associations with C. trachomatis load or disease severity. American Society for Microbiology 2014-01 /pmc/articles/PMC3911420/ /pubmed/24197878 http://dx.doi.org/10.1128/JCM.02618-13 Text en Copyright © 2014 Last et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Chlamydiology and Rickettsiology
Last, Anna R.
Roberts, Chrissy h.
Cassama, Eunice
Nabicassa, Meno
Molina-Gonzalez, Sandra
Burr, Sarah E.
Mabey, David C. W.
Bailey, Robin L.
Holland, Martin J.
Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection
title Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection
title_full Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection
title_fullStr Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection
title_full_unstemmed Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection
title_short Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection
title_sort plasmid copy number and disease severity in naturally occurring ocular chlamydia trachomatis infection
topic Chlamydiology and Rickettsiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911420/
https://www.ncbi.nlm.nih.gov/pubmed/24197878
http://dx.doi.org/10.1128/JCM.02618-13
work_keys_str_mv AT lastannar plasmidcopynumberanddiseaseseverityinnaturallyoccurringocularchlamydiatrachomatisinfection
AT robertschrissyh plasmidcopynumberanddiseaseseverityinnaturallyoccurringocularchlamydiatrachomatisinfection
AT cassamaeunice plasmidcopynumberanddiseaseseverityinnaturallyoccurringocularchlamydiatrachomatisinfection
AT nabicassameno plasmidcopynumberanddiseaseseverityinnaturallyoccurringocularchlamydiatrachomatisinfection
AT molinagonzalezsandra plasmidcopynumberanddiseaseseverityinnaturallyoccurringocularchlamydiatrachomatisinfection
AT burrsarahe plasmidcopynumberanddiseaseseverityinnaturallyoccurringocularchlamydiatrachomatisinfection
AT mabeydavidcw plasmidcopynumberanddiseaseseverityinnaturallyoccurringocularchlamydiatrachomatisinfection
AT baileyrobinl plasmidcopynumberanddiseaseseverityinnaturallyoccurringocularchlamydiatrachomatisinfection
AT hollandmartinj plasmidcopynumberanddiseaseseverityinnaturallyoccurringocularchlamydiatrachomatisinfection

Ejemplares similares