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Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis

BACKGROUND: The chemokine receptor CXCR4 plays a significant role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. However, the clinical application of CXCR4 for breast cancer prognosis is still very limited. A meta-analysis based on publi...

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Autores principales: Zhang, Zhigang, Ni, Chao, Chen, Wuzhen, Wu, Ping, Wang, Zhen, Yin, Junhua, Huang, Jian, Qiu, Fuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911796/
https://www.ncbi.nlm.nih.gov/pubmed/24475985
http://dx.doi.org/10.1186/1471-2407-14-49
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author Zhang, Zhigang
Ni, Chao
Chen, Wuzhen
Wu, Ping
Wang, Zhen
Yin, Junhua
Huang, Jian
Qiu, Fuming
author_facet Zhang, Zhigang
Ni, Chao
Chen, Wuzhen
Wu, Ping
Wang, Zhen
Yin, Junhua
Huang, Jian
Qiu, Fuming
author_sort Zhang, Zhigang
collection PubMed
description BACKGROUND: The chemokine receptor CXCR4 plays a significant role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. However, the clinical application of CXCR4 for breast cancer prognosis is still very limited. A meta-analysis based on published studies was performed with the aim of obtaining an accurate evaluation of the relationship between CXCR4 expression and the prognosis of breast cancer. METHODS: A comprehensive search strategy was used to search relevant literature in PubMed, MEDLINE and the ISI Web of Science. The correlation between CXCR4 expression and clinicopathological features and breast cancer prognosis was analyzed. This meta-analysis was carried out using Review Manager 4.2. RESULT: Thirteen eligible studies consisting of 3865 participants were included. We found that breast cancers with CXCR4 expression were associated with lymph node status (pooled RR =1.20, 95% CI: 1.01-1.43, P<0.001) and distant metastasis (pooled RR =1.52, 95% CI: 1.17-1.98, P = 0.125). CXCR4 overexpression was significantly associated with disease free survival (DFS) (RR = 0.77, 95% CI = 0.70–0.86, P = 0.554) and overall survival (OS) (RR = 0.70, 95% CI = 0.59–0.83, P = 0.329). However, there was no significant association between CXCR4 expression and some clinical parameters of breast cancer, such as tumor category, ER status, PR status, or c-erbB-2 status. CONCLUSION: Our meta-analysis showed that CXCR4 is an efficient prognostic factor for breast cancer. Overexpression of CXCR4 was significantly associated with lymph node status and distant metastasis and indicated poor overall and disease free survival.
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spelling pubmed-39117962014-02-04 Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis Zhang, Zhigang Ni, Chao Chen, Wuzhen Wu, Ping Wang, Zhen Yin, Junhua Huang, Jian Qiu, Fuming BMC Cancer Research Article BACKGROUND: The chemokine receptor CXCR4 plays a significant role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. However, the clinical application of CXCR4 for breast cancer prognosis is still very limited. A meta-analysis based on published studies was performed with the aim of obtaining an accurate evaluation of the relationship between CXCR4 expression and the prognosis of breast cancer. METHODS: A comprehensive search strategy was used to search relevant literature in PubMed, MEDLINE and the ISI Web of Science. The correlation between CXCR4 expression and clinicopathological features and breast cancer prognosis was analyzed. This meta-analysis was carried out using Review Manager 4.2. RESULT: Thirteen eligible studies consisting of 3865 participants were included. We found that breast cancers with CXCR4 expression were associated with lymph node status (pooled RR =1.20, 95% CI: 1.01-1.43, P<0.001) and distant metastasis (pooled RR =1.52, 95% CI: 1.17-1.98, P = 0.125). CXCR4 overexpression was significantly associated with disease free survival (DFS) (RR = 0.77, 95% CI = 0.70–0.86, P = 0.554) and overall survival (OS) (RR = 0.70, 95% CI = 0.59–0.83, P = 0.329). However, there was no significant association between CXCR4 expression and some clinical parameters of breast cancer, such as tumor category, ER status, PR status, or c-erbB-2 status. CONCLUSION: Our meta-analysis showed that CXCR4 is an efficient prognostic factor for breast cancer. Overexpression of CXCR4 was significantly associated with lymph node status and distant metastasis and indicated poor overall and disease free survival. BioMed Central 2014-01-29 /pmc/articles/PMC3911796/ /pubmed/24475985 http://dx.doi.org/10.1186/1471-2407-14-49 Text en Copyright © 2014 Zhang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Zhigang
Ni, Chao
Chen, Wuzhen
Wu, Ping
Wang, Zhen
Yin, Junhua
Huang, Jian
Qiu, Fuming
Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis
title Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis
title_full Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis
title_fullStr Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis
title_full_unstemmed Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis
title_short Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis
title_sort expression of cxcr4 and breast cancer prognosis: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911796/
https://www.ncbi.nlm.nih.gov/pubmed/24475985
http://dx.doi.org/10.1186/1471-2407-14-49
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