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Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis
BACKGROUND: The chemokine receptor CXCR4 plays a significant role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. However, the clinical application of CXCR4 for breast cancer prognosis is still very limited. A meta-analysis based on publi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911796/ https://www.ncbi.nlm.nih.gov/pubmed/24475985 http://dx.doi.org/10.1186/1471-2407-14-49 |
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author | Zhang, Zhigang Ni, Chao Chen, Wuzhen Wu, Ping Wang, Zhen Yin, Junhua Huang, Jian Qiu, Fuming |
author_facet | Zhang, Zhigang Ni, Chao Chen, Wuzhen Wu, Ping Wang, Zhen Yin, Junhua Huang, Jian Qiu, Fuming |
author_sort | Zhang, Zhigang |
collection | PubMed |
description | BACKGROUND: The chemokine receptor CXCR4 plays a significant role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. However, the clinical application of CXCR4 for breast cancer prognosis is still very limited. A meta-analysis based on published studies was performed with the aim of obtaining an accurate evaluation of the relationship between CXCR4 expression and the prognosis of breast cancer. METHODS: A comprehensive search strategy was used to search relevant literature in PubMed, MEDLINE and the ISI Web of Science. The correlation between CXCR4 expression and clinicopathological features and breast cancer prognosis was analyzed. This meta-analysis was carried out using Review Manager 4.2. RESULT: Thirteen eligible studies consisting of 3865 participants were included. We found that breast cancers with CXCR4 expression were associated with lymph node status (pooled RR =1.20, 95% CI: 1.01-1.43, P<0.001) and distant metastasis (pooled RR =1.52, 95% CI: 1.17-1.98, P = 0.125). CXCR4 overexpression was significantly associated with disease free survival (DFS) (RR = 0.77, 95% CI = 0.70–0.86, P = 0.554) and overall survival (OS) (RR = 0.70, 95% CI = 0.59–0.83, P = 0.329). However, there was no significant association between CXCR4 expression and some clinical parameters of breast cancer, such as tumor category, ER status, PR status, or c-erbB-2 status. CONCLUSION: Our meta-analysis showed that CXCR4 is an efficient prognostic factor for breast cancer. Overexpression of CXCR4 was significantly associated with lymph node status and distant metastasis and indicated poor overall and disease free survival. |
format | Online Article Text |
id | pubmed-3911796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39117962014-02-04 Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis Zhang, Zhigang Ni, Chao Chen, Wuzhen Wu, Ping Wang, Zhen Yin, Junhua Huang, Jian Qiu, Fuming BMC Cancer Research Article BACKGROUND: The chemokine receptor CXCR4 plays a significant role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. However, the clinical application of CXCR4 for breast cancer prognosis is still very limited. A meta-analysis based on published studies was performed with the aim of obtaining an accurate evaluation of the relationship between CXCR4 expression and the prognosis of breast cancer. METHODS: A comprehensive search strategy was used to search relevant literature in PubMed, MEDLINE and the ISI Web of Science. The correlation between CXCR4 expression and clinicopathological features and breast cancer prognosis was analyzed. This meta-analysis was carried out using Review Manager 4.2. RESULT: Thirteen eligible studies consisting of 3865 participants were included. We found that breast cancers with CXCR4 expression were associated with lymph node status (pooled RR =1.20, 95% CI: 1.01-1.43, P<0.001) and distant metastasis (pooled RR =1.52, 95% CI: 1.17-1.98, P = 0.125). CXCR4 overexpression was significantly associated with disease free survival (DFS) (RR = 0.77, 95% CI = 0.70–0.86, P = 0.554) and overall survival (OS) (RR = 0.70, 95% CI = 0.59–0.83, P = 0.329). However, there was no significant association between CXCR4 expression and some clinical parameters of breast cancer, such as tumor category, ER status, PR status, or c-erbB-2 status. CONCLUSION: Our meta-analysis showed that CXCR4 is an efficient prognostic factor for breast cancer. Overexpression of CXCR4 was significantly associated with lymph node status and distant metastasis and indicated poor overall and disease free survival. BioMed Central 2014-01-29 /pmc/articles/PMC3911796/ /pubmed/24475985 http://dx.doi.org/10.1186/1471-2407-14-49 Text en Copyright © 2014 Zhang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zhang, Zhigang Ni, Chao Chen, Wuzhen Wu, Ping Wang, Zhen Yin, Junhua Huang, Jian Qiu, Fuming Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis |
title | Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis |
title_full | Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis |
title_fullStr | Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis |
title_full_unstemmed | Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis |
title_short | Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis |
title_sort | expression of cxcr4 and breast cancer prognosis: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911796/ https://www.ncbi.nlm.nih.gov/pubmed/24475985 http://dx.doi.org/10.1186/1471-2407-14-49 |
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