Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down syndrome

Sorting nexin 27 (SNX27), a brain-enriched PDZ domain protein, regulates endocytic sorting and trafficking. Here, we show that Snx27(−/−) mice exhibit severe neuronal deficits in the hippocampus and cortex. While Snx27(+/−) mice exhibit grossly normal neuroanatomy, we find defects in synaptic functi...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Zhao, Yingjun, Zhang, Xiaofei, Badie, Hedieh, Zhou, Ying, Mu, Yangling, Loo, Li Shen, Cai, Lei, Thompson, Robert C., Yang, Bo, Chen, Yaomin, Johnson, Peter F., Wu, Chengbiao, Bu, Guojun, Mobley, William C., Zhang, Dongxian, Gage, Fred H., Ranscht, Barbara, Zhang, Yun-wu, Lipton, Stuart A., Hong, Wanjin, Xu, Huaxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911880/
https://www.ncbi.nlm.nih.gov/pubmed/23524343
http://dx.doi.org/10.1038/nm.3117

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