Use of Positron Emission Tomography for Real-Time Imaging of Biodistribution of Green Tea Catechin

The aim of this study was to achieve real-time imaging of the in vivo behavior of a green tea polyphenol, catechin, by positron emission tomography (PET). Positron-labeled 4″ -[(11)C]methyl-epigallocatechin gallate ([(11)C]Me-EGCG) was orally administered to rats, and its biodistribution was imaged...

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Autores principales: Shimizu, Kosuke, Asakawa, Tomohiro, Harada, Norihiro, Fukumoto, Dai, Tsukada, Hideo, Asai, Tomohiro, Yamada, Shizuo, Kan, Toshiyuki, Oku, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911897/
https://www.ncbi.nlm.nih.gov/pubmed/24498262
http://dx.doi.org/10.1371/journal.pone.0085520
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author Shimizu, Kosuke
Asakawa, Tomohiro
Harada, Norihiro
Fukumoto, Dai
Tsukada, Hideo
Asai, Tomohiro
Yamada, Shizuo
Kan, Toshiyuki
Oku, Naoto
author_facet Shimizu, Kosuke
Asakawa, Tomohiro
Harada, Norihiro
Fukumoto, Dai
Tsukada, Hideo
Asai, Tomohiro
Yamada, Shizuo
Kan, Toshiyuki
Oku, Naoto
author_sort Shimizu, Kosuke
collection PubMed
description The aim of this study was to achieve real-time imaging of the in vivo behavior of a green tea polyphenol, catechin, by positron emission tomography (PET). Positron-labeled 4″ -[(11)C]methyl-epigallocatechin gallate ([(11)C]Me-EGCG) was orally administered to rats, and its biodistribution was imaged for 60 min by using a small animal PET system. As the result, images of [(11)C]Me-EGCG passing through the stomach into the small intestines were observed; and a portion of it was quantitatively detected in the liver. On the other hand, intravenous injection of [(11)C]Me-EGCG resulted in a temporal accumulation of the labeled catechin in the liver, after which almost all of it was transferred to the small intestines within 60 min. In the present study, we succeeded in obtaining real-time imaging of the absorption and biodistribution of [(11)C]Me-EGCG with a PET system.
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spelling pubmed-39118972014-02-04 Use of Positron Emission Tomography for Real-Time Imaging of Biodistribution of Green Tea Catechin Shimizu, Kosuke Asakawa, Tomohiro Harada, Norihiro Fukumoto, Dai Tsukada, Hideo Asai, Tomohiro Yamada, Shizuo Kan, Toshiyuki Oku, Naoto PLoS One Research Article The aim of this study was to achieve real-time imaging of the in vivo behavior of a green tea polyphenol, catechin, by positron emission tomography (PET). Positron-labeled 4″ -[(11)C]methyl-epigallocatechin gallate ([(11)C]Me-EGCG) was orally administered to rats, and its biodistribution was imaged for 60 min by using a small animal PET system. As the result, images of [(11)C]Me-EGCG passing through the stomach into the small intestines were observed; and a portion of it was quantitatively detected in the liver. On the other hand, intravenous injection of [(11)C]Me-EGCG resulted in a temporal accumulation of the labeled catechin in the liver, after which almost all of it was transferred to the small intestines within 60 min. In the present study, we succeeded in obtaining real-time imaging of the absorption and biodistribution of [(11)C]Me-EGCG with a PET system. Public Library of Science 2014-02-03 /pmc/articles/PMC3911897/ /pubmed/24498262 http://dx.doi.org/10.1371/journal.pone.0085520 Text en © 2014 Shimizu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Shimizu, Kosuke
Asakawa, Tomohiro
Harada, Norihiro
Fukumoto, Dai
Tsukada, Hideo
Asai, Tomohiro
Yamada, Shizuo
Kan, Toshiyuki
Oku, Naoto
Use of Positron Emission Tomography for Real-Time Imaging of Biodistribution of Green Tea Catechin
title Use of Positron Emission Tomography for Real-Time Imaging of Biodistribution of Green Tea Catechin
title_full Use of Positron Emission Tomography for Real-Time Imaging of Biodistribution of Green Tea Catechin
title_fullStr Use of Positron Emission Tomography for Real-Time Imaging of Biodistribution of Green Tea Catechin
title_full_unstemmed Use of Positron Emission Tomography for Real-Time Imaging of Biodistribution of Green Tea Catechin
title_short Use of Positron Emission Tomography for Real-Time Imaging of Biodistribution of Green Tea Catechin
title_sort use of positron emission tomography for real-time imaging of biodistribution of green tea catechin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911897/
https://www.ncbi.nlm.nih.gov/pubmed/24498262
http://dx.doi.org/10.1371/journal.pone.0085520
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