Nitric Oxide-Dependent Activation of CaMKII Increases Diastolic Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes in Response to Adrenergic Stimulation

Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors. Beta-adrenergic (β-AR) tone is known to increase this leak through the activation of Ca-calmodulin-dependent protein kinase (CaMKII) and the subsequent p...

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Detalles Bibliográficos
Autores principales: Curran, Jerry, Tang, Lifei, Roof, Steve R., Velmurugan, Sathya, Millard, Ashley, Shonts, Stephen, Wang, Honglan, Santiago, Demetrio, Ahmad, Usama, Perryman, Matthew, Bers, Donald M., Mohler, Peter J., Ziolo, Mark T., Shannon, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911966/
https://www.ncbi.nlm.nih.gov/pubmed/24498331
http://dx.doi.org/10.1371/journal.pone.0087495

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