Bone Marrow-Specific Knock-In of a Non-Activatable Ikkα Kinase Mutant Influences Haematopoiesis but Not Atherosclerosis in Apoe-Deficient Mice

BACKGROUND: The Ikkα kinase, a subunit of the NF-κB-activating IKK complex, has emerged as an important regulator of inflammatory gene expression. However, the role of Ikkα-mediated phosphorylation in haematopoiesis and atherogenesis remains unexplored. In this study, we investigated the effect of a...

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Detalles Bibliográficos
Autores principales: Tilstam, Pathricia V., Gijbels, Marion J., Habbeddine, Mohamed, Cudejko, Céline, Asare, Yaw, Theelen, Wendy, Zhou, Baixue, Döring, Yvonne, Drechsler, Maik, Pawig, Lukas, Simsekyilmaz, Sakine, Koenen, Rory R., de Winther, Menno P. J., Lawrence, Toby, Bernhagen, Jürgen, Zernecke, Alma, Weber, Christian, Noels, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911989/
https://www.ncbi.nlm.nih.gov/pubmed/24498325
http://dx.doi.org/10.1371/journal.pone.0087452

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