The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration

A detailed map demonstrating the spatially restricted distribution of immune cells within the desmoplastic stroma of human pancreatic tumors opens up the field of pancreatic oncoimmunology. CD8(+) T cells located in the proximity of malignant lesions are associated with a survival advantage, suggest...

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Detalles Bibliográficos
Autores principales: Watt, Jennifer, Kocher, Hemant M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912010/
https://www.ncbi.nlm.nih.gov/pubmed/24498555
http://dx.doi.org/10.4161/onci.26788
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author Watt, Jennifer
Kocher, Hemant M
author_facet Watt, Jennifer
Kocher, Hemant M
author_sort Watt, Jennifer
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description A detailed map demonstrating the spatially restricted distribution of immune cells within the desmoplastic stroma of human pancreatic tumors opens up the field of pancreatic oncoimmunology. CD8(+) T cells located in the proximity of malignant lesions are associated with a survival advantage, suggesting the existence of immunoediting. Pancreatic stellate cells appear to dictate the infiltration of the juxtatumoral stroma by CD8(+) T cells.
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spelling pubmed-39120102014-02-04 The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration Watt, Jennifer Kocher, Hemant M Oncoimmunology Author's View A detailed map demonstrating the spatially restricted distribution of immune cells within the desmoplastic stroma of human pancreatic tumors opens up the field of pancreatic oncoimmunology. CD8(+) T cells located in the proximity of malignant lesions are associated with a survival advantage, suggesting the existence of immunoediting. Pancreatic stellate cells appear to dictate the infiltration of the juxtatumoral stroma by CD8(+) T cells. Landes Bioscience 2013-12-01 2013-10-22 /pmc/articles/PMC3912010/ /pubmed/24498555 http://dx.doi.org/10.4161/onci.26788 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Watt, Jennifer
Kocher, Hemant M
The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration
title The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration
title_full The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration
title_fullStr The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration
title_full_unstemmed The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration
title_short The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration
title_sort desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912010/
https://www.ncbi.nlm.nih.gov/pubmed/24498555
http://dx.doi.org/10.4161/onci.26788
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