Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation

We have recently described an assay for imaging interstitial collagen degradation in vivo, which allows for the identification of cell types and molecules involved in collagen turnover in the course of pathological and physiological tissue remodeling. The assay revealed a dominant role of receptor-m...

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Detalles Bibliográficos
Autores principales: Madsen, Daniel H, Bugge, Thomas H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912026/
https://www.ncbi.nlm.nih.gov/pubmed/24498566
http://dx.doi.org/10.4161/onci.27127
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author Madsen, Daniel H
Bugge, Thomas H
author_facet Madsen, Daniel H
Bugge, Thomas H
author_sort Madsen, Daniel H
collection PubMed
description We have recently described an assay for imaging interstitial collagen degradation in vivo, which allows for the identification of cell types and molecules involved in collagen turnover in the course of pathological and physiological tissue remodeling. The assay revealed a dominant role of receptor-mediated intracellular collagen degradation by M2-polarized macrophages in extracellular matrix turnover.
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spelling pubmed-39120262014-02-04 Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation Madsen, Daniel H Bugge, Thomas H Oncoimmunology Author's View We have recently described an assay for imaging interstitial collagen degradation in vivo, which allows for the identification of cell types and molecules involved in collagen turnover in the course of pathological and physiological tissue remodeling. The assay revealed a dominant role of receptor-mediated intracellular collagen degradation by M2-polarized macrophages in extracellular matrix turnover. Landes Bioscience 2013-12-01 2013-12-09 /pmc/articles/PMC3912026/ /pubmed/24498566 http://dx.doi.org/10.4161/onci.27127 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Madsen, Daniel H
Bugge, Thomas H
Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation
title Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation
title_full Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation
title_fullStr Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation
title_full_unstemmed Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation
title_short Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation
title_sort imaging collagen degradation in vivo highlights a key role for m2-polarized macrophages in extracellular matrix degradation
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912026/
https://www.ncbi.nlm.nih.gov/pubmed/24498566
http://dx.doi.org/10.4161/onci.27127
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