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Telomere Length in Peripheral Blood Leukocytes Is Associated with Risk of Colorectal Cancer in Chinese Population

BACKGROUND: Human telomeres, tandem repeats of TTAGGG nucleotides at the ends of chromosomes, are essential for maintaining genomic integrity and stability. Results of previous epidemiologic studies about the association of telomere length with risk of colorectal cancer (CRC) have been conflicting....

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Autores principales: Qin, Qin, Sun, Jingwen, Yin, Jieyun, Liu, Li, Chen, Jigui, Zhang, Yuxing, Li, TingTing, Shi, Yun, Wei, Sheng, Nie, Shaofa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912164/
https://www.ncbi.nlm.nih.gov/pubmed/24498432
http://dx.doi.org/10.1371/journal.pone.0088135
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author Qin, Qin
Sun, Jingwen
Yin, Jieyun
Liu, Li
Chen, Jigui
Zhang, Yuxing
Li, TingTing
Shi, Yun
Wei, Sheng
Nie, Shaofa
author_facet Qin, Qin
Sun, Jingwen
Yin, Jieyun
Liu, Li
Chen, Jigui
Zhang, Yuxing
Li, TingTing
Shi, Yun
Wei, Sheng
Nie, Shaofa
author_sort Qin, Qin
collection PubMed
description BACKGROUND: Human telomeres, tandem repeats of TTAGGG nucleotides at the ends of chromosomes, are essential for maintaining genomic integrity and stability. Results of previous epidemiologic studies about the association of telomere length with risk of colorectal cancer (CRC) have been conflicting. METHODS: A case-control study was conducted in a Han population in Wuhan, central China. The relative telomere length (RTL) was measured in peripheral blood leukocytes (PBLs) using quantitative real-time polymerase chain reaction (PCR) in 628 CRC cases and 1,256 age and sex frequency matched cancer-free controls. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression models to evaluate the association between RTL and CRC risk. RESULTS: Using median RTL in the controls as the cutoff, individuals with shorter RTL were associated with a significantly increased risk of CRC (adjusted OR = 1.27, 95%CI: 1.05–1.55). When participants were further categorized into 3 and 4 groups according to the tertile and quartile RTL values of controls, significant relationships were still observed between shorter RTL and increased CRC risk (OR per tertile = 1.13, 95%CI: 1.00–1.28, P (trend) = 0.045; OR per quartile = 1.12, 95%CI: 1.03–1.23, P (trend) = 0.012). In stratified analyses, significant association between shorter RTL and increased CRC risk was found in females, individuals younger than 60 years old, never smokers and never drinkers. CONCLUSIONS: This study suggested that short telomere length in PBLs was significantly associated with an increased risk of CRC in Chinese Han population. Further validation in large prospective studies and investigation of the biologic mechanisms are warranted.
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spelling pubmed-39121642014-02-04 Telomere Length in Peripheral Blood Leukocytes Is Associated with Risk of Colorectal Cancer in Chinese Population Qin, Qin Sun, Jingwen Yin, Jieyun Liu, Li Chen, Jigui Zhang, Yuxing Li, TingTing Shi, Yun Wei, Sheng Nie, Shaofa PLoS One Research Article BACKGROUND: Human telomeres, tandem repeats of TTAGGG nucleotides at the ends of chromosomes, are essential for maintaining genomic integrity and stability. Results of previous epidemiologic studies about the association of telomere length with risk of colorectal cancer (CRC) have been conflicting. METHODS: A case-control study was conducted in a Han population in Wuhan, central China. The relative telomere length (RTL) was measured in peripheral blood leukocytes (PBLs) using quantitative real-time polymerase chain reaction (PCR) in 628 CRC cases and 1,256 age and sex frequency matched cancer-free controls. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression models to evaluate the association between RTL and CRC risk. RESULTS: Using median RTL in the controls as the cutoff, individuals with shorter RTL were associated with a significantly increased risk of CRC (adjusted OR = 1.27, 95%CI: 1.05–1.55). When participants were further categorized into 3 and 4 groups according to the tertile and quartile RTL values of controls, significant relationships were still observed between shorter RTL and increased CRC risk (OR per tertile = 1.13, 95%CI: 1.00–1.28, P (trend) = 0.045; OR per quartile = 1.12, 95%CI: 1.03–1.23, P (trend) = 0.012). In stratified analyses, significant association between shorter RTL and increased CRC risk was found in females, individuals younger than 60 years old, never smokers and never drinkers. CONCLUSIONS: This study suggested that short telomere length in PBLs was significantly associated with an increased risk of CRC in Chinese Han population. Further validation in large prospective studies and investigation of the biologic mechanisms are warranted. Public Library of Science 2014-02-03 /pmc/articles/PMC3912164/ /pubmed/24498432 http://dx.doi.org/10.1371/journal.pone.0088135 Text en © 2014 Qin et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Qin, Qin
Sun, Jingwen
Yin, Jieyun
Liu, Li
Chen, Jigui
Zhang, Yuxing
Li, TingTing
Shi, Yun
Wei, Sheng
Nie, Shaofa
Telomere Length in Peripheral Blood Leukocytes Is Associated with Risk of Colorectal Cancer in Chinese Population
title Telomere Length in Peripheral Blood Leukocytes Is Associated with Risk of Colorectal Cancer in Chinese Population
title_full Telomere Length in Peripheral Blood Leukocytes Is Associated with Risk of Colorectal Cancer in Chinese Population
title_fullStr Telomere Length in Peripheral Blood Leukocytes Is Associated with Risk of Colorectal Cancer in Chinese Population
title_full_unstemmed Telomere Length in Peripheral Blood Leukocytes Is Associated with Risk of Colorectal Cancer in Chinese Population
title_short Telomere Length in Peripheral Blood Leukocytes Is Associated with Risk of Colorectal Cancer in Chinese Population
title_sort telomere length in peripheral blood leukocytes is associated with risk of colorectal cancer in chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912164/
https://www.ncbi.nlm.nih.gov/pubmed/24498432
http://dx.doi.org/10.1371/journal.pone.0088135
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