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Stem cell sources for tooth regeneration: current status and future prospects

Stem cells are capable of renewing themselves through cell division and have the remarkable ability to differentiate into many different types of cells. They therefore have the potential to become a central tool in regenerative medicine. During the last decade, advances in tissue engineering and ste...

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Autores principales: Otsu, Keishi, Kumakami-Sakano, Mika, Fujiwara, Naoki, Kikuchi, Kazuko, Keller, Laetitia, Lesot, Hervé, Harada, Hidemitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912331/
https://www.ncbi.nlm.nih.gov/pubmed/24550845
http://dx.doi.org/10.3389/fphys.2014.00036
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author Otsu, Keishi
Kumakami-Sakano, Mika
Fujiwara, Naoki
Kikuchi, Kazuko
Keller, Laetitia
Lesot, Hervé
Harada, Hidemitsu
author_facet Otsu, Keishi
Kumakami-Sakano, Mika
Fujiwara, Naoki
Kikuchi, Kazuko
Keller, Laetitia
Lesot, Hervé
Harada, Hidemitsu
author_sort Otsu, Keishi
collection PubMed
description Stem cells are capable of renewing themselves through cell division and have the remarkable ability to differentiate into many different types of cells. They therefore have the potential to become a central tool in regenerative medicine. During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. Investigation of embryonic and adult (tissue) stem cells as potential cell sources for tooth regeneration has led to many promising results. However, technical and ethical issues have hindered the availability of these cells for clinical application. The recent discovery of induced pluripotent stem (iPS) cells has provided the possibility to revolutionize the field of regenerative medicine (dentistry) by offering the option of autologous transplantation. In this article, we review the current progress in the field of stem cell-based tooth regeneration and discuss the possibility of using iPS cells for this purpose.
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spelling pubmed-39123312014-02-18 Stem cell sources for tooth regeneration: current status and future prospects Otsu, Keishi Kumakami-Sakano, Mika Fujiwara, Naoki Kikuchi, Kazuko Keller, Laetitia Lesot, Hervé Harada, Hidemitsu Front Physiol Physiology Stem cells are capable of renewing themselves through cell division and have the remarkable ability to differentiate into many different types of cells. They therefore have the potential to become a central tool in regenerative medicine. During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. Investigation of embryonic and adult (tissue) stem cells as potential cell sources for tooth regeneration has led to many promising results. However, technical and ethical issues have hindered the availability of these cells for clinical application. The recent discovery of induced pluripotent stem (iPS) cells has provided the possibility to revolutionize the field of regenerative medicine (dentistry) by offering the option of autologous transplantation. In this article, we review the current progress in the field of stem cell-based tooth regeneration and discuss the possibility of using iPS cells for this purpose. Frontiers Media S.A. 2014-02-04 /pmc/articles/PMC3912331/ /pubmed/24550845 http://dx.doi.org/10.3389/fphys.2014.00036 Text en Copyright © 2014 Otsu, Kumakami-Sakano, Fujiwara, Kikuchi, Keller, Lesot and Harada. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Otsu, Keishi
Kumakami-Sakano, Mika
Fujiwara, Naoki
Kikuchi, Kazuko
Keller, Laetitia
Lesot, Hervé
Harada, Hidemitsu
Stem cell sources for tooth regeneration: current status and future prospects
title Stem cell sources for tooth regeneration: current status and future prospects
title_full Stem cell sources for tooth regeneration: current status and future prospects
title_fullStr Stem cell sources for tooth regeneration: current status and future prospects
title_full_unstemmed Stem cell sources for tooth regeneration: current status and future prospects
title_short Stem cell sources for tooth regeneration: current status and future prospects
title_sort stem cell sources for tooth regeneration: current status and future prospects
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912331/
https://www.ncbi.nlm.nih.gov/pubmed/24550845
http://dx.doi.org/10.3389/fphys.2014.00036
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