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Stem cell sources for tooth regeneration: current status and future prospects
Stem cells are capable of renewing themselves through cell division and have the remarkable ability to differentiate into many different types of cells. They therefore have the potential to become a central tool in regenerative medicine. During the last decade, advances in tissue engineering and ste...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912331/ https://www.ncbi.nlm.nih.gov/pubmed/24550845 http://dx.doi.org/10.3389/fphys.2014.00036 |
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author | Otsu, Keishi Kumakami-Sakano, Mika Fujiwara, Naoki Kikuchi, Kazuko Keller, Laetitia Lesot, Hervé Harada, Hidemitsu |
author_facet | Otsu, Keishi Kumakami-Sakano, Mika Fujiwara, Naoki Kikuchi, Kazuko Keller, Laetitia Lesot, Hervé Harada, Hidemitsu |
author_sort | Otsu, Keishi |
collection | PubMed |
description | Stem cells are capable of renewing themselves through cell division and have the remarkable ability to differentiate into many different types of cells. They therefore have the potential to become a central tool in regenerative medicine. During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. Investigation of embryonic and adult (tissue) stem cells as potential cell sources for tooth regeneration has led to many promising results. However, technical and ethical issues have hindered the availability of these cells for clinical application. The recent discovery of induced pluripotent stem (iPS) cells has provided the possibility to revolutionize the field of regenerative medicine (dentistry) by offering the option of autologous transplantation. In this article, we review the current progress in the field of stem cell-based tooth regeneration and discuss the possibility of using iPS cells for this purpose. |
format | Online Article Text |
id | pubmed-3912331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39123312014-02-18 Stem cell sources for tooth regeneration: current status and future prospects Otsu, Keishi Kumakami-Sakano, Mika Fujiwara, Naoki Kikuchi, Kazuko Keller, Laetitia Lesot, Hervé Harada, Hidemitsu Front Physiol Physiology Stem cells are capable of renewing themselves through cell division and have the remarkable ability to differentiate into many different types of cells. They therefore have the potential to become a central tool in regenerative medicine. During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. Investigation of embryonic and adult (tissue) stem cells as potential cell sources for tooth regeneration has led to many promising results. However, technical and ethical issues have hindered the availability of these cells for clinical application. The recent discovery of induced pluripotent stem (iPS) cells has provided the possibility to revolutionize the field of regenerative medicine (dentistry) by offering the option of autologous transplantation. In this article, we review the current progress in the field of stem cell-based tooth regeneration and discuss the possibility of using iPS cells for this purpose. Frontiers Media S.A. 2014-02-04 /pmc/articles/PMC3912331/ /pubmed/24550845 http://dx.doi.org/10.3389/fphys.2014.00036 Text en Copyright © 2014 Otsu, Kumakami-Sakano, Fujiwara, Kikuchi, Keller, Lesot and Harada. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Otsu, Keishi Kumakami-Sakano, Mika Fujiwara, Naoki Kikuchi, Kazuko Keller, Laetitia Lesot, Hervé Harada, Hidemitsu Stem cell sources for tooth regeneration: current status and future prospects |
title | Stem cell sources for tooth regeneration: current status and future prospects |
title_full | Stem cell sources for tooth regeneration: current status and future prospects |
title_fullStr | Stem cell sources for tooth regeneration: current status and future prospects |
title_full_unstemmed | Stem cell sources for tooth regeneration: current status and future prospects |
title_short | Stem cell sources for tooth regeneration: current status and future prospects |
title_sort | stem cell sources for tooth regeneration: current status and future prospects |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912331/ https://www.ncbi.nlm.nih.gov/pubmed/24550845 http://dx.doi.org/10.3389/fphys.2014.00036 |
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