Genomic and transcriptomic plasticity in treatment-naïve ovarian cancer

Intra-tumor heterogeneity is a hallmark of many cancers and may lead to therapy resistance or interfere with personalized treatment strategies. Here, we combined topographic mapping of somatic breakpoints and transcriptional profiling to probe intra-tumor heterogeneity of treatment-naïve stage IIIC/...

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Detalles Bibliográficos
Autores principales: Hoogstraat, Marlous, de Pagter, Mirjam S., Cirkel, Geert A., van Roosmalen, Markus J., Harkins, Timothy T., Duran, Karen, Kreeftmeijer, Jennifer, Renkens, Ivo, Witteveen, Petronella O., Lee, Clarence C., Nijman, Isaac J., Guy, Tanisha, van ’t Slot, Ruben, Jonges, Trudy N., Lolkema, Martijn P., Koudijs, Marco J., Zweemer, Ronald P., Voest, Emile E., Cuppen, Edwin, Kloosterman, Wigard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912411/
https://www.ncbi.nlm.nih.gov/pubmed/24221193
http://dx.doi.org/10.1101/gr.161026.113

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